Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents

被引：8

作者：

Ribeiro, Ricardo ^{[1
,2
]}

Costa, Lia ^{[1
]}

Pinto, Eugenia ^{[2
,3
]}

Sousa, Emilia ^{[1
,2
]}

Fernandes, Carla ^{[1
,2
]}

Fernandez, Javier

机构：

[1] Univ Porto, Fac Farm, Dept Ciencias Quim, Lab Quim Organ & Farmaceut, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[2] Interdisciplinary Ctr Marine & Environm Res CIIMAR, Edificio Terminal Cruzeiros Porto Leixoes,Ave Gen, P-4050208 Matosinhos, Portugal

[3] Univ Porto, Fac Farm, Dept Ciencias Biol, Lab Microbiol, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

来源：

MARINE DRUGS | 2023年 / 21卷 / 12期

关键词：

antiparasitic activity; cyclic peptides; leishmaniasis; malaria; marine resources; trypanosomiasis; MOLLUSK ELYSIA-RUFESCENS; KAHALALIDE F ANALOGS; IN-VITRO; TOXOPLASMA-GONDII; NATURAL-PRODUCT; TRYPANOSOMA-CRUZI; DRUG DISCOVERY; PHASE-I; A-C; JASPLAKINOLIDE AFFECTS;

D O I：

10.3390/md21120609

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance. There is an urgent need to find new, safe, effective, and affordable antiparasitic drugs. Marine-derived cyclic peptides have been increasingly screened as candidates for developing new drugs. Therefore, in this review, a systematic analysis of the scientific literature was performed and 25 marine-derived cyclic peptides with antiparasitic activity (1-25) were found. Antimalarial activity is the most reported (51%), followed by antileishmanial (27%) and antitrypanosomal (20%) activities. Some compounds showed promising antiparasitic activity at the nM scale, being active against various parasites. The mechanisms of action and targets for some of the compounds have been investigated, revealing different strategies against parasites.

引用

页数：27

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