The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks

被引：6

作者：

Tissink, Elleke ^{[1
]}

Werme, Josefin ^{[1
]}

de Lange, Siemon C. ^{[1
,2
]}

Savage, Jeanne E. ^{[1
]}

Wei, Yongbin ^{[1
,3
]}

de Leeuw, Christiaan A. ^{[1
]}

Nagel, Mats ^{[1
]}

Posthuma, Danielle ^{[1
,4
]}

van den Heuvel, Martijn P. ^{[1
,4
]}

机构：

[1] Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Complex Trait Genet, Amsterdam Neurosci, NL-1081 HV Amsterdam, Netherlands

[2] Netherlands Inst Neurosci, Dept Sleep & Cognit, NL-1105 BA Amsterdam, Netherlands

[3] Beijing Univ Posts & Telecommun, Sch Artificial Intelligence, Beijing 100876, Peoples R China

[4] Vrije Univ, Amsterdam Univ Med Ctr, Dept Clin Genet, Sect Complex Trait Genet,Med Ctr, NL-1081 HZ Amsterdam, Netherlands

来源：

ENEURO | 2023年 / 10卷 / 04期

基金：

欧洲研究理事会;

关键词：

connectivity; GWAS; networks; neuroimaging; resting-state; structure-function; GENOME-WIDE ASSOCIATION; DEFAULT-MODE; HUMAN CONNECTOME; BRAIN; HERITABILITY; DIFFUSION; REGIONS; EXPRESSION; DISCOVERY; FRAMEWORK;

D O I：

10.1523/ENEURO.0242-22.2023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Functional connectivity within resting-state networks (RSN-FC) is vital for cognitive functioning. RSN-FC is her-itable and partially translates to the anatomic architecture of white matter, but the genetic component of struc-tural connections of RSNs (RSN-SC) and their potential genetic overlap with RSN-FC remain unknown. Here, we perform genome-wide association studies (Ndiscovery = 24,336; Nreplication = 3412) and annotation on RSN-SC and RSN-FC. We identify genes for visual network-SC that are involved in axon guidance and synaptic functioning. Genetic variation in RSN-FC impacts biological processes relevant to brain disorders that previ-ously were only phenotypically associated with RSN-FC alterations. Correlations of the genetic components of RSNs are mostly observed within the functional domain, whereas less overlap is observed within the structural domain and between the functional and structural domains. This study advances the understanding of the complex functional organization of the brain and its structural underpinnings from a genetics viewpoint.

引用

页数：1

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