A clinical focus on oral tolerance in the development, prevention, and management of food allergy

被引：7

作者：

Macdougall, Jessica ^{[1
]}

Kim, Edwin H. ^{[1
]}

机构：

[1] Univ North Carolina Sch Med, Dept Pediat Allergy & Immunol, 5004 Mary Ellen Jones Bldg, 116 Manning Dr CB 8035, Chapel Hill, NC 27599 USA

来源：

CELLULAR IMMUNOLOGY | 2023年 / 386卷

关键词：

Food allergy; Peanut allergy; Desensitization; Sustained unresponsiveness; Tolerance; Oral tolerance; Oral immunotherapy; MOUSE MODEL; IMMUNOTHERAPY; SENSITIZATION;

D O I：

10.1016/j.cellimm.2023.104693

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Food allergy impacts up to 10 % of the population and can result in life-threatening anaphylactic reactions. The pathogenesis of food allergy is not entirely understood but the disruption in naturally occurring oral tolerance is presumed to be involved. Research has been directed not only toward prevention of food allergy but on the restoration of oral tolerance by various means including immunotherapy (oral, sublingual, and epicutaneous), as well as adjunctive therapies including biologicals and probiotics. This review paper briefly discusses the involvement of oral tolerance in the pathogenesis of food allergy and how food allergy might be prevented; however, the main focus is on the potential for restoration of oral tolerance with various treatment modalities (oral immunotherapy with and without adjunctive therapies).

引用

页数：6

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