Preoperative CT and survival data for patients undergoing resection of colorectal liver metastases

被引:11
作者
Simpson, Amber L. [1 ,2 ]
Peoples, Jacob [1 ]
Creasy, John M. [3 ]
Fichtinger, Gabor [1 ]
Gangai, Natalie [4 ]
Keshavamurthy, Krishna N. [4 ]
Lasso, Andras [1 ]
Shia, Jinru [5 ]
D'Angelica, Michael I. [6 ]
Do, Richard K. G. [4 ]
机构
[1] Queens Univ, Sch Comp, Kingston, ON, Canada
[2] Queens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada
[3] Oregon Clin, Portland, OR USA
[4] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY USA
[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY USA
[6] Mem Sloan Kettering Canc Ctr, Dept Surg, Hepatopancreatobiliary Serv, New York, NY USA
关键词
HEPATIC RESECTION; TEXTURE ANALYSIS; CANCER; CHEMOTHERAPY; RECURRENCE; HETEROGENEITY; INFORMATION; SITE;
D O I
10.1038/s41597-024-02981-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The liver is a common site for the development of metastases in colorectal cancer. Treatment selection for patients with colorectal liver metastases (CRLM) is difficult; although hepatic resection will cure a minority of CRLM patients, recurrence is common. Reliable preoperative prediction of recurrence could therefore be a valuable tool for physicians in selecting the best candidates for hepatic resection in the treatment of CRLM. It has been hypothesized that evidence for recurrence could be found via quantitative image analysis on preoperative CT imaging of the future liver remnant before resection. To investigate this hypothesis, we have collected preoperative hepatic CT scans, clinicopathologic data, and recurrence/survival data, from a large, single-institution series of patients (n = 197) who underwent hepatic resection of CRLM. For each patient, we also created segmentations of the liver, vessels, tumors, and future liver remnant. The largest of its kind, this dataset is a resource that may aid in the development of quantitative imaging biomarkers and machine learning models for the prediction of post-resection hepatic recurrence of CRLM.
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页数:6
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