Beyond membrane components: uncovering the intriguing world of fungal sphingolipid synthesis and regulation

被引：10

作者：

Usmani, Sana Akhtar ^{[1
]}

Kumar, Mohit ^{[2
,3
,5
]}

Arya, Khushboo ^{[1
]}

Ali, Basharat ^{[2
,3
]}

Bhardwaj, Nitin ^{[4
]}

Gaur, Naseem Akhtar ^{[5
]}

Prasad, Rajendra ^{[2
,3
]}

Singh, Ashutosh ^{[1
]}

机构：

[1] Univ Lucknow, Dept Biochem, Lucknow 226024, Uttar Pradesh, India

[2] Amity Univ Gurgaon, Amity Inst Integrat Sci & Hlth, Gurgaon, Haryana, India

[3] Amity Univ Gurgaon, Amity Inst Biotechnol, Gurgaon, Haryana, India

[4] Gurukula Kangri Vishwavidyalaya, Dept Zool & Environm Sci, Haridwar 249404, Uttarakhand, India

[5] Int Ctr Genet Engn & Biotechnol, New Delhi 110067, India

来源：

RESEARCH IN MICROBIOLOGY | 2023年 / 174卷 / 07期

关键词：

Sphingolipid; Fungi; Biosynthesis; Degradation; Regulation; INOSITOL PHOSPHORYLCERAMIDE SYNTHASE; LONG-CHAIN BASES; FATTY-ACID ELONGATION; SACCHAROMYCES-CEREVISIAE; GLUCOSYLCERAMIDE SYNTHASE; CRYPTOCOCCUS-NEOFORMANS; CERAMIDE SYNTHASES; CANDIDA-ALBICANS; SERINE PALMITOYLTRANSFERASE; FUNCTIONAL-CHARACTERIZATION;

D O I：

10.1016/j.resmic.2023.104087

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sphingolipids (SLs) are essential to fungal survival and represent a major class of structural and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous fungi make them an ideal drug target. Several studies have contributed towards the functional characterization of specific SL metabolism genes, which have been complemented by advanced lipidomics methods which allow accurate identification and quantification of lipid structures and pathway mapping. These studies have provided a better understanding of SL biosynthesis, degradation and regulation networks in filamentous fungi, which are discussed and elaborated here. (c) 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页数：11

共 138 条

[41] Sphingolipids and their metabolism in physiology and disease [J].