Necrotizing fasciitis: A highly fatal infection

Backgrounds. - Necrotizing fasciitis is a severe bacterial infection characterized by involvement of all skin's layers, including the superficial fascia. Diagnosis and treatment must be as quick as possible. Once suspected, extensive surgical debridement is required. Methods. - All necrotizing fasciitis, managed in our hospital in Dijon, during the period from January 2011 to May 2021, were retrospectively analyzed. Demographics characteristics of patients, biological parameters, and type of bacteria were collected. Statistical analysis was performed on the cost of hospitalization, as well as on the death rate between type I and II NF and the speed of management. Student's t-test and Chi2 test were performed with a significant level P < 0.05. Findings. - A total of 65 patients were included over the period. The mean age was 68.8 years. The average length of stay was 32.4 days, with an average cost of 79,305 . The main locations were the lower limbs (57%) and the perineum (35%). Cost of hospitalization did not differ between type I and II (P = 0.21), unlike mortality rate (P = 0.003). Furthermore, the mortality rate according to the speed of management did not vary in our series (P = 0.45). Conclusion. - Necrotizing fasciitis is quickly fatal if left untreated. Early diagnosis, combined with surgical debridement and probabilistic antibiotic therapy are required. Our study shows the impact of necrotizing fasciitis in terms of cost to society and the importance of prevention of certain risk factors. A global management of the patient is necessary to increase the survival rate. (c) 2022 Elsevier Masson SAS. All rights reserved.