T cell control of SARS-CoV-2: When, which, and where?

被引：6

作者：

Diniz, Mariana O. ^{[1
]}

Maini, Mala K. ^{[1
]}

Swadling, Leo ^{[1
]}

机构：

[1] UCL, Inst Immun & Transplantat, Div Infect & Immun, Pears Bldg, London WC1E 6BT, England

来源：

SEMINARS IN IMMUNOLOGY | 2023年 / 70卷

基金：

英国惠康基金;

关键词：

SARS-CoV-2-specific T cells; Abortive infection; Tissue-resident; Mucosal vaccination; PROTECTION; VIRUS; INFLUENZA; RESPONSES; IMMUNITY; INFECTION; COVID-19; VACCINATION; ACTIVATION; CHALLENGE;

D O I：

10.1016/j.smim.2023.101828

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Efficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider which of their qualitative features favour efficient control of infection. We highlight how studies of SARS-CoV-2 and other coronaviridae in animals and humans have provided important lessons on the optimal timing (When), functionality and specificity (Which), and location (Where) of antiviral T cells. We discuss the clinical implications, particularly for the development of next-generation vaccines, and emphasise areas requiring further study.

引用

页数：17

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