Biosynthesis, structure and biological function of cholesterol glucoside in Helicobacter pylori: A review

被引:0
|
作者
Zhang, Lanchi [1 ]
Xie, Jingri [2 ,3 ]
机构
[1] Heilongjiang Univ Chinese Med, Harbin, Heilongjiang Pr, Peoples R China
[2] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Harbin, Heilongjiang Pr, Peoples R China
[3] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Harbin 150040, Heilongjiang Pr, Peoples R China
关键词
cholesterol-& alpha; -D-glucopyranoside; Helicobacter pylori (H pylori); Infection; ALPHA-GLUCOSYLTRANSFERASE; LIPID RAFTS; RECOGNITION; PHASE; PHOSPHOLIPASE; METABOLISM; INFECTION; AUTOPHAGY;
D O I
10.1097/MD.0000000000034911
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Helicobacter pylori (H pylori) is a common pathogen, and about 50% of the world population have been infected with it, so the infection of H pylori has been an urgent public health problem worldwide. H pylori has evolved a variety of strategies to help itself colonize, adapt to the environment and proliferate. Cholesterol glucoside (CG), a characteristic substance in H pylori, is related to the membrane stability, morphology, inflammation induction and immune evasion of H pylori. Therefore, CG may be a new target to weaken the infection effect of H pylori. The biosynthesis process, structure and biological function of CG specific to H pylori, as well as anti-CG drugs are discussed and analyzed in this review, in order to explore whether the inhibition of CG synthesis can be an effective strategy to eradicate H pylori.
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页数:7
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