Dual Photoredox/Nickel-Catalyzed Dehydrative Difluoroalkylation of Benzyl Alcohols for the Synthesis of Allylic gem-Difluorides

被引：2
|
作者：
Bai, Yuyang [1 ]
Cao, Liping [1 ]
Li, Siyuan [2 ,3 ]
Zhang, Guang'an [2 ,3 ]
Liu, Yingguo [1 ]
Zhao, Fengqian [2 ,3 ]
Wu, Junliang [2 ,3 ]
机构：
[1] Zhengzhou Univ, Henan Inst Adv Technol, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[3] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 35期
关键词：
ALKENES; ALKYNES; FLUORINE;
D O I：
10.1021/acs.orglett.3c02248
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A photoredox/Lewis acid cooperative catalytic system has been developed for the construction of C-vinyl-C-Rf bonds through the dehydrative difluoroalkylation of benzyl alcohols. A variety of allylic gem-difluorides could be obtained in moderate yields with good to excellent E/Z selectivity. In addition, several control experiments have been explored, and a possible mechanism was proposed for this process.
引用
收藏
页码：6511 / 6516
页数：6
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