Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair

被引:30
|
作者
Li, Shanshan [1 ]
Yang, Cheng [1 ]
Li, Junqiang [1 ]
Zhang, Chao [1 ]
Zhu, Liaoliao [1 ]
Song, Yang [1 ]
Guo, Yongdong [1 ]
Wang, Ronglin [1 ]
Gan, Dongxue [1 ]
Shi, Jingjie [1 ]
Ma, Peixiang [1 ]
Gao, Fei [2 ]
Su, Haichuan [1 ]
机构
[1] Air Force Med Univ, Affiliated Hosp 2, Dept Oncol, 569 Xinsi Rd, Xian, Peoples R China
[2] Shanghai Univ, Inst Translat Med, Ctr Peptide Funct Mat & Innovat Drugs, 99 ShangDa Rd, Shanghai City, Peoples R China
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2023年 / 18卷
关键词
Pluronic F127; F127-CHO; F127-NH2; F127-DA; wound healing and repair; ANTIBACTERIAL ACTIVITY; MULTIFUNCTIONAL HYDROGEL; PHOTOTHERMAL THERAPY; ARTIFICIAL SKIN; NANOPARTICLES; ADHESIVE; F-127; GEL; ENCAPSULATION; GELATION;
D O I
10.2147/IJN.S418534
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Pluronic F127 hydrogel biomaterial has garnered considerable attention in wound healing and repair due to its remarkable properties including temperature sensitivity, injectability, biodegradability, and maintain a moist wound environment. This compre-hensive review provides an in-depth exploration of the recent advancements in Pluronic F127-derived hydrogels, such as F127-CHO, F127-NH2, and F127-DA, focusing on their applications in the treatment of various types of wounds, ranging from burns and acute wounds to infected wounds, diabetic wounds, cutaneous tumor wounds, and uterine scars. Furthermore, the review meticulously examines the intricate interaction mechanisms employed by these hydrogels within the wound microenvironment. By elucidating the underlying mechanisms, discussing the strengths and weaknesses of Pluronic F127, analyzing the current state of wound healing development, and expanding on the trend of targeting mitochondria and cells with F127 as a nanomaterial. The review enhances our understanding of the therapeutic effects of these hydrogels aims to foster the development of effective and safe wound-healing modalities. The valuable insights provided this review have the potential to inspire novel ideas for clinical treatment and facilitate the advancement of innovative wound management approaches.
引用
收藏
页码:4485 / 4505
页数:21
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