PET assessment of acute gastrointestinal graft versus host disease

被引:5
作者
Scott, Ashleigh P. P. [1 ,2 ]
Henden, Andrea [1 ,2 ,3 ]
Kennedy, Glen A. A. [1 ,2 ]
Tey, Siok-Keen [1 ,2 ,3 ]
机构
[1] Royal Brisbane & Womens Hosp, Dept Haematol & Bone Marrow Transplant, Brisbane, Qld, Australia
[2] Univ Queensland, Sch Med, Brisbane, Qld, Australia
[3] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
关键词
STEM-CELL TRANSPLANTATION; CONFOCAL LASER ENDOMICROSCOPY; CONTRAST-ENHANCED ULTRASOUND; BONE-MARROW-TRANSPLANTATION; INFLAMMATORY-BOWEL-DISEASE; INTESTINAL GRAFT; ACUTE GVHD; TRANSLOCATOR PROTEIN; ENDOSCOPIC EVALUATION; PROGNOSTIC-FACTORS;
D O I
10.1038/s41409-023-02038-9
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Acute gastrointestinal graft versus host disease (GI-GVHD) is a common complication following allogeneic haematopoietic cell transplantation (HCT), and is characterised by severe morbidity, frequent treatment-refractoriness, and high mortality. Early, accurate identification of GI-GVHD could allow for therapeutic interventions to ameliorate its severity, improve response rates and survival; however, standard endoscopic biopsy is inadequately informative in terms of diagnostic sensitivity or outcome prediction. In an era where rapid technological and laboratory advances have dramatically expanded our understanding of GI-GVHD biology and potential therapeutic targets, there is substantial scope for novel investigations that can precisely guide GI-GVHD management. In particular, the combination of tissue-based biomarker assessment (plasma cytokines, faecal microbiome) and molecular imaging by positron emission tomography (PET) offers the potential for non-invasive, real-time in vivo assessment of donor:recipient immune activity within the GI tract for GI-GVHD prediction or diagnosis. In this article, we review the evidence regarding GI-GVHD diagnosis, and examine the potential roles and translational opportunities posed by these novel diagnostic tools, with a focus on the evolving role of PET.
引用
收藏
页码:973 / 979
页数:7
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