Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology

被引：8

作者：

Fang, Wenzhuo ^{[1
]}

Yang, Ming ^{[1
]}

Liu, Meng ^{[1
]}

Jin, Yangwang ^{[1
]}

Wang, Yuhui ^{[1
]}

Yang, Ranxing ^{[1
]}

Wang, Ying ^{[1
]}

Zhang, Kaile ^{[1
]}

Fu, Qiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Urol, 600 Yi Shan Rd, Shanghai 200233, Peoples R China

来源：

PHARMACEUTICS | 2023年 / 15卷 / 06期

基金：

上海市自然科学基金;

关键词：

3D bioprinting; hydrogel; bioink; tissue engineering; bionic scaffold; NF-KAPPA-B; COLONY-STIMULATING FACTOR; FIBROIN-NANOHYDROXYAPATITE SCAFFOLD; EXTRACELLULAR-MATRIX BIOINK; ZINC-OXIDE NANOPARTICLES; METAL-ORGANIC-FRAMEWORKS; HYPOXIA-INDUCIBLE FACTOR; GROWTH-FACTOR EXPRESSION; MESENCHYMAL STEM-CELLS; IN-VITRO;

D O I：

10.3390/pharmaceutics15061700

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The regeneration of biological tissues in medicine is challenging, and 3D bioprinting offers an innovative way to create functional multicellular tissues. One common way in bioprinting is bioink, which is one type of the cell-loaded hydrogel. For clinical application, however, the bioprinting still suffers from satisfactory performance, e.g., in vascularization, effective antibacterial, immunomodulation, and regulation of collagen deposition. Many studies incorporated different bioactive materials into the 3D-printed scaffolds to optimize the bioprinting. Here, we reviewed a variety of additives added to the 3D bioprinting hydrogel. The underlying mechanisms and methodology for biological regeneration are important and will provide a useful basis for future research.

引用

页数：55

共 327 条

[11] Chitosan membrane as a wound-healing dressing: Characterization and clinical application [J].