Direct synthesis of alkylated 4-hydroxycoumarin derivatives via a cascade Cu-catalyzed dehydrogenation/conjugate addition sequence

被引:9
|
作者
Chen, Zhiliang [1 ,2 ]
Li, Hongyi [2 ]
Liao, Yanjing [2 ]
Wang, Mengqi [1 ,2 ]
Su, Weiping [2 ]
机构
[1] Fuzhou Univ, Coll Chem, Fuzhou 350108, Peoples R China
[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fujian Sci & Technol Innovat Lab Optoelect Informa, Fuzhou 350002, Peoples R China
基金
中国国家自然科学基金;
关键词
Compendex;
D O I
10.1039/d3cc01960h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An efficient approach for the direct synthesis of alkylated 4-hydroxycoumarin derivatives via a Cu-catalyzed cascade dehydrogenation/conjugate addition sequence starting from simple saturated ketones and 4-hydroxycoumarins has been developed. This protocol features excellent functional-group tolerance, easy scale-up, and a broad substrate scope including bioactive molecules. More importantly, a series of marketed drugs, such as warfarin, acenocoumarol, coumachlor, and coumafuryl, can be obtained by this method.
引用
收藏
页码:6686 / 6689
页数:4
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