Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM

被引：76

作者：

Bassetti, Matteo ^{[1
,2
]}

Giacobbe, Daniele R. ^{[1
,2
]}

Agvald-Ohman, Christina ^{[3
]}

Akova, Murat ^{[4
]}

Alastruey-Izquierdo, Ana ^{[5
,6
]}

Arikan-Akdagli, Sevtap ^{[7
]}

Azoulay, Elie ^{[8
,9
]}

Blot, Stijn ^{[10
,11
]}

Cornely, Oliver A. ^{[12
,13
,14
,15
,16
,17
,18
]}

Cuenca-Estrella, Manuel ^{[5
]}

de Lange, Dylan W. ^{[19
]}

De Rosa, Francesco G. ^{[20
]}

De Waele, Jan J. ^{[21
]}

Dimopoulos, George ^{[22
]}

Garnacho-Montero, Jose ^{[23
]}

Hoenigl, Martin ^{[24
,25
,26
]}

Kanj, Souha S. ^{[27
,28
]}

Koehler, Philipp ^{[12
,13
,14
,15
,29
]}

Kullberg, Bart J. ^{[30
,31
]}

Lamoth, Frederic ^{[32
,33
,34
,35
,36
]}

Lass-Floerl, Cornelia ^{[37
]}

Maertens, Johan ^{[38
]}

Martin-Loeches, Ignacio ^{[39
]}

Munoz, Patricia ^{[40
,41
,42
,43
]}

Poulakou, Garyphallia ^{[44
]}

Rello, Jordi ^{[45
,46
,47
,48
]}

Sanguinetti, Maurizio ^{[49
,50
]}

Taccone, Fabio S. ^{[51
]}

Timsit, Jean-Francois ^{[52
,53
]}

Torres, Antoni ^{[54
,55
,56
,57
]}

Vazquez, Jose A. ^{[58
]}

Wauters, Joost ^{[59
]}

Asperges, Erika ^{[60
]}

Cortegiani, Andrea ^{[61
,62
]}

Grecchi, Cecilia ^{[63
]}

Karaiskos, Ilias ^{[64
]}

Le Bihan, Clement ^{[65
]}

Mercier, Toine ^{[66
,67
]}

Mortensen, Klaus L. ^{[68
]}

Peghin, Maddalena ^{[69
]}

Rebuffi, Chiara ^{[70
]}

Tejada, Sofia ^{[45
,48
]}

Vena, Antonio ^{[1
,2
]}

Zuccaro, Valentina ^{[60
]}

Scudeller, Luigia ^{[71
]}

Calandra, Thierry ^{[33
,34
,35
,36
]}

机构：

[1] Univ Genoa, Dept Hlth Sci DISSAL, Genoa, Italy

[2] IRCCS Osped Policlin San Martino, Infect Dis Unit, Lgo R Benzi 10, I-16132 Genoa, Italy

[3] Karolinska Univ Hosp Huddinge, Anaesthesiol & Intens Care, Stockholm, Sweden

[4] Hacettepe Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkiye

[5] Inst Salud Carlos III, Mycol Reference Lab, Natl Ctr Microbiol, Madrid, Spain

[6] Ctr Invest Biomed Red CIBER Enfermedades Infecc C, Madrid, Spain

[7] Hacettepe Univ, Fac Med, Dept Med Microbiol, Ankara, Turkiye

[8] Univ Paris, Paris, France

[9] Hop St Louis, Serv Med Intens & Reanimat, AP HP, Paris, France

[10] Univ Ghent, Fac Med & Hlth Sci, Dept Internal Med & Pediat, Ghent, Belgium

[11] Univ Queensland, Fac Med, UQ Ctr Clin Res, Brisbane, Australia

[12] Univ Cologne, Dep Internal Med 1, Ctr Integrated Oncol Aachen Bonn Cologne Duesseld, Cologne, Germany

[13] Univ Cologne, Fac Med, Excellence Ctr Med Mycol ECMM, Cologne, Germany

[14] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[15] Univ Cologne, Fac Med, Cologne, Germany

[16] Univ Cologne, Univ Hosp Cologne, Inst Translat Res, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

[17] Univ Cologne, Univ Hosp Cologne, Clin Trials Ctr Cologne ZKS Koln, Cologne, Germany

[18] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, Cologne, Germany

[19] Univ Utrecht, Univ Med Ctr, Dept Intens Care Med, Utrecht, Netherlands

[20] Univ Turin, Dept Med Sci, Infect Dis, Turin, Italy

[21] Ghent Univ Hosp, Dept Crit Care Med, Ghent, Belgium

[22] Natl & Kapodistrian Univ Athens, Univ Hosp Attikon, Attikon Med Sch, Dept Crit Care, Athens, Greece

[23] Virgen del Rocio Univ Hosp, Intens Care Unit, Seville, Spain

[24] Med Univ Graz, Dept Internal Med, Div Infect Dis, Graz, Austria

[25] BioTechMed, Graz, Austria

[26] Med Univ Graz, ECMM Excellence Ctr Clin Mycol, Translat Mycol Working Grp, Graz, Austria

[27] Amer Univ Beirut, Div Infect Dis, Med Ctr, Beirut, Lebanon

[28] Amer Univ Beirut, Ctr Infect Dis Res, Med Ctr, Beirut, Lebanon

[29] Univ Cologne, Univ Hosp Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

[30] Radboud Univ Nijmegen, Dept Med, Med Ctr, Nijmegen, Netherlands

[31] Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, Nijmegen, Netherlands

[32] Lausanne Univ Hosp, Inst Microbiol, Lausanne, Switzerland

[33] Univ Lausanne, Lausanne, Switzerland

[34] Lausanne Univ Hosp, Serv Immunol & Allergy, Lausanne, Switzerland

[35] Lausanne Univ Hosp, Ctr Human Immunol Lausanne, Dept Med, Lausanne, Switzerland

[36] Lausanne Univ Hosp, Dept Lab Med & Pathol, Inst Pathol, Lausanne, Switzerland

[37] Med Univ Innsbruck, Inst Hyg & Med Microbiol, Innsbruck, Austria

[38] Univ Ziekenhuis Leuven, Leuven, Belgium

[39] St James Hosp, Dept Intens Care Med, Multidisciplinary Intens Care Res Org MICRO, Dublin, Ireland

[40] Hosp Gen Univ Gregorio Maranon, Clin Microbiol & Infect Dis, Madrid, Spain

[41] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain

[42] Ctr Invest Biomed Red CIBER Enfermedades Resp CIB, Madrid, Spain

[43] Univ Complutense Madrid, Fac Med, Med Dept, Madrid, Spain

[44] Natl & Kapodistrian Univ, Sotiria Gen Hosp, Sch Med, Dept Internal Med 3, Athens, Greece

[45] Vall dHebron Inst Res VHIR, Clin Res Epidemiol Pneumonia & Sepsis CRIPS, Barcelona, Spain

[46] Univ Nimes Montpellier, Clin Res ICU, CHU Nimes, Nimes, France

[47] Univ Int Catalunya UIC, Med Dept, Sant Cugat Del Valles, Spain

[48] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain

[49] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Lab & Infettivol, Rome, Italy

[50] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnol Base, Clin Intensivol & Perioperatorie, Rome, Italy

来源：

INTENSIVE CARE MEDICINE | 2024年 / 50卷 / 04期

关键词：

Invasive fungal diseases; Aspergillus; Candida; Consensus; Definitions; Diagnosis; Intensive care unit; Research; PULMONARY ASPERGILLOSIS; CRITICALLY-ILL; INFECTIONS; EPIDEMIOLOGY; MULTICENTER; CANDIDIASIS; MANAGEMENT; DIAGNOSIS; OUTCOMES; PREDICTORS;

D O I：

10.1007/s00134-024-07341-7

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

PurposeThe aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs).MethodsAfter a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method.ResultsStandardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.

引用

页码：502 / 515

页数：14

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