Putting Hybrid Nanomaterials to Work for Biomedical Applications

Hybrid nanomaterials have found use in many biomedical applications. This article provides a comprehensive review of the principles, techniques, and recent advancements in the design and fabrication of hybrid nanomaterials for biomedicine. We begin with an introduction to the general concept of material hybridization, followed by a discussion of how this approach leads to materials with additional functionality and enhanced performance. We then highlight hybrid nanomaterials in the forms of nanostructures, nanocomposites, metal-organic frameworks, and biohybrids, including their fabrication methods. We also showcase the use of hybrid nanomaterials to advance biomedical engineering in the context of nanomedicine, regenerative medicine, diagnostics, theranostics, and biomanufacturing. Finally, we offer perspectives on challenges and opportunities. This article discusses recent advances in developing hybrid nanomaterials for biomedicine. We highlight features and opportunities enabled by material hybridization, including the capabilities of targeting, controlled release, multiplex assay, and multi-functionality, as well as biomanufacturing. Several examples are examined to highlight the opportunities and challenges in applying this class of materials to advance biomedicine.+ image