Atrial fibrillation and stroke: State-of-the-art and future directions

被引：48

作者：

Elsheikh, Sandra ^{[1
,2
,3
,4
,7
]}

Hill, Andrew ^{[1
,2
,4
]}

Irving, Greg ^{[1
,2
,5
]}

Lip, Gregory Y. H. ^{[1
,2
,3
,6
]}

Abdul-Rahim, Azmil H. ^{[2
]}

机构：

[1] Univ Liverpool, Liverpool John Moores Univ, Liverpool Ctr Cardiovasc Sci, Liverpool, England

[2] Liverpool Heart & Chest Hosp, Liverpool, England

[3] Univ Liverpool, Inst Life Course & Med Sci, Cardiovasc & Metab Med, Liverpool, England

[4] Mersey & West Lancashire Teaching Hosp NHS Trust, St Helens, England

[5] Edge Hill Univ, Hlth Res Inst, Fac Hlth & Social Care, Ormskirk, England

[6] Aalborg Univ, Danish Ctr Hlth Serv Res, Dept Clin Med, Aalborg, Denmark

[7] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Cardiovasc & Metab Med, 6 West Derby St, Liverpool L7 8TX, England

来源：

CURRENT PROBLEMS IN CARDIOLOGY | 2024年 / 49卷 / 01期

关键词：

atrial fibrillation (AF); stroke; oral anticoagulant (OAC); thrombolytic therapy; left atrial appendage occlusion; ACUTE ISCHEMIC-STROKE; EARLY RHYTHM-CONTROL; CRYPTOGENIC STROKE; APPENDAGE CLOSURE; UNDETERMINED SOURCE; EMBOLIC STROKE; RISK-FACTOR; ORAL ANTICOAGULATION; CAROTID PLAQUE; CAUSATIVE CLASSIFICATION;

D O I：

10.1016/j.cpcardiol.2023.102181

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) and stroke remain a major cause of morbidity and mortality. The two conditions shared common co-morbidities and risk factors. AF-related strokes are associated with worse clinical outcomes and higher mortality compared to non-AF-related. Early detection of AF is vital for prevention. While various scores have been developed to predict AF in such a high-risk group, they are yet to incorporated into clinical guidelines. Novel markers and predictors of AF including coronary and intracranial arterial calcification have also been studied. There are also ongoing debates on the management of acute stroke in patients with AF, and those who experienced breakthrough stroke while on oral anticoagulants. We provided an overview of the complex interplay between AF and stroke, as well as the treatment and secondary prevention of stroke in AF. We also comprehensively discussed the current evidence and the ongoing conundrums, and highlighted the future directions on the topic.

引用

页数：22

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