Relations between nonmotor manifestations and motor disorders in patients with benign essential blepharospasm

PurposeTo evaluate the relations between nonmotor manifestations (dry eye, mood disorders, and sleep disturbance) and motor disorders in patients with benign essential blepharospasm (BEB), and to determine whether relieving motor disorders by botulinum neurotoxin can improve the nonmotor manifestations.MethodsIn this prospective case series study, 123 BEB patients were enrolled for evaluations. Among them, 28 patients underwent botulinum neurotoxin therapy and attended another two postoperative visits at 1 month and 3 months. Motor severity was measured with Jankovic Rating Scale (JRS) and Blepharospasm Disability Index (BSDI). We assessed dry eye using OSDI questionnaire, Schirmer test, tear break-up time (TBUT), tear meniscus height, lipid layer thickness (LLT) and corneal fluorescence staining. Zung's Self-rating Anxiety and Depression Scale (SAS, SDS) and Pittsburgh Sleep Quality Index (PSQI) were for mood status and sleep quality evaluations.ResultsPatients with dry eye or mood disorders had higher JRS scores (5.78 & PLUSMN; 1.13, 5.97 & PLUSMN; 1.30) than those without (5.12 & PLUSMN; 1.40, 5.50 & PLUSMN; 1.16; P = 0.039, 0.019, respectively). BSDI values of patients with sleep disturbance (14.61 & PLUSMN; 4.71) was higher than those without (11.89 & PLUSMN; 5.44, P = 0.006). Correlations were found between JRS, BSDI and SAS, SDS, PSQI, OSDI, TBUT. Botulinum neurotoxin effectively relieved JRS, BSDI and improved PSQI, OSDI, TBUT, LLT (8.11 & PLUSMN; 5.81, 21.77 & PLUSMN; 15.76, 5.04 & PLUSMN; 2.15 s, 79.61 & PLUSMN; 24.11 nm) at the 1-month visit compared to baseline (9.75 & PLUSMN; 5.60, 33.58 & PLUSMN; 13.27, 4.14 & PLUSMN; 2.21 s, 62.33 & PLUSMN; 22.01 nm; P = 0.006, < 0.001, = 0.027, < 0.001, respectively).ConclusionsThe BEB patients with dry eye, mood disorders, or sleep disturbance had more severe motor disorders. Motor severity was associated with the severity of the nonmotor manifestations. Relieving motor disorders by botulinum neurotoxin was effective in improving dry eye and sleep disturbance.