A Clinical and Pathophysiological Overview of Intestinal and Systemic Diseases Associated with Pancreatic Disorders: Causality or Casualty?

被引：6

作者：

Bellocchi, Maria Cristina Conti ^{[1
]}

Crino, Stefano Francesco ^{[1
]}

De Marchi, Giulia ^{[2
]}

De Pretis, Nicolo ^{[2
]}

Ofosu, Andrew ^{[3
]}

Caldart, Federico ^{[2
]}

Ciccocioppo, Rachele ^{[2
]}

Frulloni, Luca ^{[2
]}

机构：

[1] Univ Verona, Pancreas Inst, Diagnost & Intervent Endoscopy Pancreas, I-37134 Verona, Italy

[2] Univ Verona, Pancreas Inst, Dept Med, Gastroenterol Unit, I-37134 Verona, Italy

[3] Univ Cincinnati, Div Gastroenterol & Hepatol, Coll Med, Cincinnati, OH 45267 USA

来源：

BIOMEDICINES | 2023年 / 11卷 / 05期

关键词：

pancreatic disorders; inflammatory bowel disease; IgG4-related disease; autoimmune pancreatitis; exocrine pancreatic insufficiency; celiac disease; INFLAMMATORY-BOWEL-DISEASE; CELIAC-DISEASE; AUTOIMMUNE PANCREATITIS; ULCERATIVE-COLITIS; GASTROINTESTINAL INVOLVEMENT; IGG4-RELATED DISEASE; CROHNS-DISEASE; POLYARTERITIS-NODOSA; RISK; FEATURES;

D O I：

10.3390/biomedicines11051393

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relationship between chronic intestinal disease, including inflammatory bowel disease (IBD) and celiac disease (CelD), and pancreatic disorders has been little investigated. Although an increased risk of acute pancreatitis (AP), exocrine pancreatic insufficiency with or without chronic pancreatitis, and chronic asymptomatic pancreatic hyperenzymemia have been described in these patients, the pathogenetic link remains unclear. It may potentially involve drugs, altered microcirculation, gut permeability/motility with disruption of enteric-mediated hormone secretion, bacterial translocation, and activation of the gut-associated lymphoid tissue related to chronic inflammation. In addition, the risk of pancreatic cancer seems to be increased in both IBD and CelD patients with unknown pathogenesis. Finally, other systemic conditions (e.g., IgG4-related disease, sarcoidosis, vasculitides) might affect pancreatic gland and the intestinal tract with various clinical manifestations. This review includes the current understandings of this enigmatic association, reporting a clinical and pathophysiological overview about this topic.

引用

页数：21

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