Treatment outcomes of multidrug-resistant TB with selective use of new drugs

被引：4

作者：

Kwon, Y-S. ^{[1
]}

Shin, J. E. ^{[2
]}

Kang, H. ^{[3
]}

Jeon, D. ^{[4
]}

Yim, J-J. ^{[5
]}

Shim, T. S. ^{[2
,6
]}

机构：

[1] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Internal Med, Med Sch, Gwangju, South Korea

[2] Univ Ulsan, Asan Med Ctr, Div Pulm & Crit Care Med, Coll Med, Seoul, South Korea

[3] Masan Natl TB Hosp, Dept Chest Med, Masan, South Korea

[4] Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Yangsan, South Korea

[5] Seoul Natl Univ, Dept Internal Med, Div Pulm & Crit Care Med, Coll Med, Seoul, South Korea

[6] Univ Ulsan, Asan Med Ctr, Div Pulm & Crit Care Med, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2023年 / 27卷 / 01期

关键词：

bedaquiline; delamanid; multidrug-resistant tuberculosis; expert committee; TUBERCULOSIS; BEDAQUILINE; DELAMANID;

D O I：

10.5588/ijtld.22.0343

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

SETTING: This was a nationwide cohort study.O B J E C T I V E : To assess the treatment outcomes in patients with multidrug-resistant TB (MDR-TB) who underwent treatment guided by a national TB expert review committee in South Korea.DESIGN: We enrolled all patients with MDR-TB submitted for approval for the use of new TB drugs, including bedaquiline and delamanid, from 2016 to 2019. Patients were classified into two groups: those on new TB drugs and those not on new TB drugs. We compared the final treatment outcomes between the groups and analysed the prognostic factors.RES U LT S : Of a total of 785 patients, respectively 754 (96.1%) and 31 (3.9%) were classified into the "new TB drugs' group and "no new TB drugs"group. The new TB drugs group had a higher acid-fast bacilli smear positivity rate and higher resistance rate to second-line injectable drugs or fluoroquinolones. Of all the patients, 97.8% achieved culture conversion (97.7% vs. 100%), and 80.4% achieved treatment success (80.2% vs. 86.7%); there was no difference between the two groups.O N C L U S I O N S : New drugs are currently recommend-ed for use in all MDR-TB treatment regimens, and the use of new drugs, as determined by an expert committee, in mainly quinolone-susceptible MDR-TB, did not compromise the treatment success rate.

引用

页码：55 / +

页数：7

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