Ganglioside GM1 produces stable, short, and cytotoxic Aβ40 protofibrils

被引：7
作者：
Kumar, Manjeet [1 ]
Ivanova, Magdalena I. [2 ]
Ramamoorthy, Ayyalusamy [1 ]
机构：
[1] Univ Michigan, Michigan Neurosci Inst, Dept Chem Biomed Engn Macromol Sci & Engn, Biophys, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 46期
基金：
美国国家卫生研究院;
关键词：
AMYLOID BETA-PROTEIN; THIOFLAVIN-T-BINDING; ALZHEIMERS-DISEASE; AGGREGATION; FIBRILS; MECHANISM; MEMBRANES; FORM; SEED;
D O I：
10.1039/d3cc02186f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Monosialoganglioside GM1-bound amyloid beta-peptides have been found in patients' brains exhibiting early pathological changes of Alzheimer's disease. Herein, we report the ability of non-micellar GM1 to modulate A beta(40) aggregation resulting in the formation of stable, short, rod-like, and cytotoxic A beta(40) protofibrils with the ability to potentiate both A beta(40) and A beta(42) aggregation.
引用
收藏
页码：7040 / 7043
页数：4
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