Current advances in immunotherapy for atypical teratoid rhabdoid tumor (ATRT)

被引：10

作者：

Tran, Son ^{[1
]}

Plant-Fox, Ashley S. ^{[2
,3
]}

Chi, Susan N. ^{[4
]}

Narendran, Aru ^{[1
,5
,6
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Dept Oncol & Pediat, Calgary, AB, Canada

[2] Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Stem Cell Transplant & Neurooncol, Chicago, IL USA

[3] Northwestern Univ, Feinberg Sch Med, Chicago, IL USA

[4] Dana Farber Boston Childrens Canc & Blood Disorder, Dept Pediat Oncol, Boston, MA USA

[5] Univ Calgary, Cumming Sch Med, Dept Oncol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

[6] Univ Calgary, Cumming Sch Med, Dept Pediat, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

来源：

NEURO-ONCOLOGY PRACTICE | 2023年 / 10卷 / 04期

关键词：

Atypical teratoid rhabdoid tumor (ATRT); immunotherapy; immunooncology (IO); tumor microenvironment; pediatric; GROWTH-FACTOR RECEPTOR; GLYPICAN; 3; EXPRESSION; LIGAND; TERATOID/RHABDOID TUMORS; T-CELLS; CHILDREN; EFFICACY; VIRUS; RADIATION; SURVIVAL;

D O I：

10.1093/nop/npad005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Atypical teratoid rhabdoid tumors (ATRT) are rare and aggressive embryonal tumors of central nervous system that typically affect children younger than 3 years of age. Given the generally poor outcomes of patients with ATRT and the significant toxicities associated with conventional multi-modal therapies, there is an urgent need for more novel approaches to treat ATRT, one such approach being immunotherapy. The recent rise of large-scale, multicenter interdisciplinary studies has delineated several molecular and genetic characteristics unique to ATRT. This review aims to describe currently available data on the tumor immune microenvironment of ATRT and its specific subtypes and to summarize the emerging clinical and preclinical results of immunotherapy-based approaches. It will also highlight the evolving knowledge of epigenetics on immunomodulation in this epigenetically influenced tumor, which may help guide the development of effective immunotherapeutic approaches in the future.

引用

页码：322 / 334

页数：13

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