A role for MCH neuron firing in modulating hippocampal plasticity threshold

被引：0

作者：

Harris, Julia J. ^{[1
,2
,3
]}

Burdakov, Denis ^{[1
,3
,4
,5
,6
,7
]}

机构：

[1] Francis Crick Inst, Sensory Circuits & Neurotechnol Lab, London, England

[2] Imperial Coll London, Dept Life Sci, London, England

[3] Francis Crick Inst, Syst Neurosci & Energy Control Lab, London, England

[4] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, CH-8603 Schwerzenbach, Switzerland

[5] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Inst Neurosci, CH-8603 Schwerzenbach, Switzerland

[6] Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Dept Hlth Sci & Technol, CH-8603 Schwerzenbach, Switzerland

[7] Neurosci Ctr Zurich, CH-8057 Zurich, Switzerland

来源：

PEPTIDES | 2024年 / 172卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Melanin-concentrating hormone; MCH; Hippocampus; Synaptic plasticity; Optogenetics; TERM SYNAPTIC PLASTICITY; GRANULE CELLS; TRANSMISSION; SLEEP; INHIBITION; OREXIN; STIMULATION; GLUTAMATE; MEMORY; AREA;

D O I：

10.1016/j.peptides.2023.171128

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been revealed that hypothalamic neurons containing the peptide, melanin-concentrating hormone (MCH) can influence learning [1] and memory formation [2], but the cellular mechanisms by which they perform this function are not well understood. Here, we examine the role of MCH neural input to the hippocampus, and show in vitro that optogenetically increasing MCH axon activity facilitates hippocampal plasticity by lowering the threshold for synaptic potentiation. These results align with increasing evidence that MCH neurons play a regulatory role in learning, and reveal that this could be achieved by modulating plasticity thresholds in the hippocampus.

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页数：7

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