A role for MCH neuron firing in modulating hippocampal plasticity threshold

被引：0
作者：
Harris, Julia J. [1 ,2 ,3 ]
Burdakov, Denis [1 ,3 ,4 ,5 ,6 ,7 ]
机构：
[1] Francis Crick Inst, Sensory Circuits & Neurotechnol Lab, London, England
[2] Imperial Coll London, Dept Life Sci, London, England
[3] Francis Crick Inst, Syst Neurosci & Energy Control Lab, London, England
[4] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, CH-8603 Schwerzenbach, Switzerland
[5] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Inst Neurosci, CH-8603 Schwerzenbach, Switzerland
[6] Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Dept Hlth Sci & Technol, CH-8603 Schwerzenbach, Switzerland
[7] Neurosci Ctr Zurich, CH-8057 Zurich, Switzerland
来源：
PEPTIDES | 2024年 / 172卷
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
Melanin-concentrating hormone; MCH; Hippocampus; Synaptic plasticity; Optogenetics; TERM SYNAPTIC PLASTICITY; GRANULE CELLS; TRANSMISSION; SLEEP; INHIBITION; OREXIN; STIMULATION; GLUTAMATE; MEMORY; AREA;
D O I：
10.1016/j.peptides.2023.171128
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It has been revealed that hypothalamic neurons containing the peptide, melanin-concentrating hormone (MCH) can influence learning [1] and memory formation [2], but the cellular mechanisms by which they perform this function are not well understood. Here, we examine the role of MCH neural input to the hippocampus, and show in vitro that optogenetically increasing MCH axon activity facilitates hippocampal plasticity by lowering the threshold for synaptic potentiation. These results align with increasing evidence that MCH neurons play a regulatory role in learning, and reveal that this could be achieved by modulating plasticity thresholds in the hippocampus.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Working memory performance correlates with prefrontal-hippocampal theta interactions but not with prefrontal neuron firing rates
    Hyman, James M.
    Zilli, Eric A.
    Paley, Amanda M.
    Hasselmo, Michael E.
    FRONTIERS IN INTEGRATIVE NEUROSCIENCE, 2010, 4
  • [22] VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy
    Cunha-Reis, Diana
    Caulino-Rocha, Ana
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 14
  • [23] Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
    Yu, Xu-Ben
    Zhong, Kai-Long
    Chen, Chuang
    Fu, Jing
    Chen, Fang
    Zhou, Hong-Min
    Zhang, Xiu-Hua
    Kim, Kwonseop
    Pan, Jing-Ye
    PSYCHOPHARMACOLOGY, 2024, 241 (01) : 75 - 88
  • [24] Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction
    Wu, Wei-Feng
    Chen, Chen
    Lin, Jia-Tao
    Jiao, Xin-Hao
    Dong, Wei
    Wan, Jie
    Liu, Qiang
    Qiu, Yong-Kang
    Sun, Ao
    Liu, Yi-Qi
    Jin, Chun-Hui
    Huang, He
    Zheng, Hui
    Zhou, Cheng-Hua
    Wu, Yu-Qing
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2024, 29 (01)
  • [25] THE ROLE OF STRUCTURAL PLASTICITY AND SYNAPTIC CONSOLIDATION FOR MEMORY AND AMNESIA IN A MODEL OF CORTICO-HIPPOCAMPAL INTERPLAY
    Knoblauch, A.
    CONNECTIONIST MODELS OF BEHAVIOUR AND COGNITION II, 2009, 18 : 79 - 90
  • [26] The Role of Hippocampal Structural Synaptic Plasticity in Repetitive Transcranial Magnetic Stimulation to Improve Cognitive Function in Male SAMP8 Mice
    Ma, Jiang
    Wang, Jinhua
    Lv, Chaonan
    Pang, Jingjuan
    Han, Bing
    Gen, Yuan
    Wang, Mingwei
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 41 (01) : 137 - 144
  • [27] Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?
    Balschun, D
    Wolfer, DP
    Gass, P
    Mantamadiotis, T
    Welzl, H
    Schütz, G
    Frey, JU
    Lipp, HP
    JOURNAL OF NEUROSCIENCE, 2003, 23 (15) : 6304 - 6314
  • [28] PLASTICITY OF INTRINSIC FIRING RESPONSE GAIN IN PRINCIPAL HIPPOCAMPAL NEURONS FOLLOWING PILOCARPINE-INDUCED STATUS EPILEPTICUS
    Tamir, Idit
    Daninos, Moshe
    Yaari, Yoel
    NEUROSCIENCE, 2017, 357 : 325 - 337
  • [29] Spike Timing-Dependent Plasticity in the CA1 Pyramidal Neuron in a Modeled Hippocampal Circuit
    H. X. Ren
    Sh. Q. Liu
    X. C. Zhang
    Y. J. Zeng
    Neurophysiology, 2015, 47 : 264 - 270
  • [30] Spike Timing-Dependent Plasticity in the CA1 Pyramidal Neuron in a Modeled Hippocampal Circuit
    Ren, H. X.
    Liu, Sh. Q.
    Zhang, X. C.
    Zeng, Y. J.
    NEUROPHYSIOLOGY, 2015, 47 (04) : 264 - 270
12345