Optimal Liver Transplantation Criteria for Hepatocellular Carcinoma

被引：3

作者：

Yilma, Mignote ^{[1
,2
]}

Mehta, Neil ^{[3
]}

机构：

[1] Univ Calif San Francisco, Dept Surg, 513 Parnassus Ave,S-321, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Natl Clinician Scholars Program, 513 Parnassus Ave,S-321, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Connie Frank Transplant Ctr, Dept Med, 400 Parnassus Ave,7th Floor, San Francisco, CA 94143 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2024年 / 33卷 / 01期

关键词：

Hepatocellular carcinoma; Liver transplantation; AFP; Locoregional therapy; Downstaging; Milan criteria; ALPHA-FETOPROTEIN; SURVIVAL BENEFIT; TUMOR SIZE; RECURRENCE; SELECTION; VALIDATION; CANDIDATES; MODEL; WAIT; EXPERIENCE;

D O I：

10.1016/j.soc.2023.06.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

LT continues to be the optimal treatment for HCC. Considerations for LT among this patient population must take into consideration organ demand and supply, as well as tumor progression with risk of recurrence post-LT. In the United States, Milan (and UNOS-DS for those beyond Milan) criteria have been used to maximize the num-ber of years gained by LT versus by alternative treatments. Advances in LRT have allowed us to downstage patients to within Milan criteria with newer pre-LT selection criteria incorporating dynamic and additional biomarkers as well as imaging modality to risk-stratify patients as we continue to look for the optimal LT cutoff for patients with HCC. Although it is impossible to compare all the LT selection models, the optimal LT criteria should be transplant-center specific, accounting for organ availability (DDLT versus LLDT) and dynamic response to LRT.

引用

页码：133 / 142

页数：10

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