State-of-the-art review and update of in vivo models of necrotizing enterocolitis

被引:7
作者
Bautista, Geoanna M. [1 ]
Cera, Anjali J. [1 ]
Chaaban, Hala [2 ]
McElroy, Steven J. [1 ]
机构
[1] Univ Calif Sacramento, Dept Pediat, Div Neonatol, Sacramento, CA 95616 USA
[2] Univ Oklahoma Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK USA
来源
FRONTIERS IN PEDIATRICS | 2023年 / 11卷
关键词
NEC = necrotizing enterocolitis; animal model; preclinical (in vivo) studies; intestinal injury; necrotizing; intestinal diseases; intestine; NITRIC-OXIDE SYNTHASE; TOLL-LIKE RECEPTOR-4; NEONATAL-RAT MODEL; INTESTINAL INJURY; ANIMAL-MODELS; PANETH CELLS; ENTERAL NUTRITION; MILK; ISCHEMIA; BACTERIA;
D O I
10.3389/fped.2023.1161342
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
NEC remains one of the most common causes of mortality and morbidity in preterm infants. Animal models of necrotizing enterocolitis (NEC) have been crucial in improving our understanding of this devastating disease and identifying biochemical pathways with therapeutic potential. The pathogenesis of NEC remains incompletely understood, with no specific entity that unifies all infants that develop NEC. Therefore, investigators rely on animal models to manipulate variables and provide a means to test interventions, making them valuable tools to enhance our understanding and prevent and treat NEC. The advancements in molecular analytic tools, genetic manipulation, and imaging modalities and the emergence of scientific collaborations have given rise to unique perspectives and disease correlates, creating novel pathways of investigation. A critical review and understanding of the current phenotypic considerations of the highly relevant animal models of NEC are crucial to developing novel therapeutic and preventative strategies for NEC.
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页数:15
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