Study on Synergistic Anti-Inflammatory Effect of Typical Functional Components of Extracts of Ginkgo Biloba Leaves

被引：11
作者：
Zhang, Lihu [1 ,2 ,3 ]
Fang, Xianying [2 ,4 ]
Sun, Jihu [1 ]
Su, Erzheng [3 ]
Cao, Fuliang [3 ]
Zhao, Linguo [2 ,3 ]
机构：
[1] Jiangsu Vocat Coll Med, Dept Pharm, Yancheng 224005, Peoples R China
[2] Nanjing Forestry Univ, Jiangsu Co Innovat Ctr Efficient Proc & Utilizat F, Nanjing 210037, Peoples R China
[3] Nanjing Forestry Univ, Co Innovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China
[4] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 03期
关键词：
ginkgo biloba extract (EGB); synergism; anti-inflammatory; ginkgo flavone; ginkgolide; DEEP EUTECTIC SOLVENTS; FACTOR-KAPPA-B; INHIBITION; ACTIVATION; EGB761;
D O I：
10.3390/molecules28031377
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There are some differences in the anti-inflammatory activities of four typical components in EGB (extracts of ginkgo biloba leaves), and there is also a synergistic relationship. The order of inhibiting the NO-release ability of single functional components is OA > GF > OPC > G. Ginkgolide (G), proanthocyanidins (OPC), and organic acids (OA) all have synergistic effects on ginkgo flavonoids (GF). GF:OA (1:9) is the lowest interaction index among all complexes, showing the strongest synergy. The anti-inflammatory mechanism of the compound affects the expression of p-JNK, p-P38, and p-ERK1/2 proteins by inhibiting the expression of iNOS and COX2 genes on NFKB and MAPK pathways. This also provides a research basis for the development of anti-inflammatory deep-processing products of EGB.
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页数：13
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