Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study

被引：7

作者：

Liu, Dan ^{[1
]}

Aziz, N. Ahmad ^{[1
,2
]}

Pehlivan, Goekhan ^{[1
]}

Breteler, Monique M. B. ^{[1
,3
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Populat Hlth Sci, Venusberg Campus 1,Bldg 99, D-53127 Bonn, Germany

[2] Univ Bonn, Fac Med, Dept Neurol, Bonn, Germany

[3] Univ Bonn, Inst Med Biometry Informat & Epidemiol IMBIE, Fac Med, Bonn, Germany

来源：

GEROSCIENCE | 2023年 / 45卷 / 03期

关键词：

Biological age; Epigenetic age acceleration; Cardiovascular aging; DNA METHYLATION; RISK; METAANALYSIS; ASSOCIATION; PREDICTION; MORTALITY; DISEASE; INDEX;

D O I：

10.1007/s11357-022-00714-0

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Individuals with a similar chronological age can exhibit marked differences in cardiovascular risk profiles, but it is unknown whether this variation is related to different rates of biological aging. Therefore, we investigated the relation between nine domains of cardiovascular function and four epigenetic age acceleration estimators (i.e., AgeAccel.Horvath, AgeAccel.Hannum, AgeAccelPheno, and AgeAccelGrim), derived from DNA methylation profiles. Among 4194 participants (mean age 54.2 years (range 30.0-95.0)) from the Rhineland Study, an ongoing population-based cohort study in Bonn, Germany, epigenetic age acceleration increased by 0.19-1.84 years per standard deviation (SD) increase in cardiovascular risk across multiple domains, including measures of kidney function, adiposity, and a composite cardiovascular risk score. Measures of inflammation and glucose homeostasis were associated with AgeAccel.Hannum, AgeAccelPheno, and AgeAccelGrim, but not with AgeAccel.Horvath. Moreover, effect sizes were larger for AgeAccelPheno and AgeAccelGrim than for AgeAccel.Horvath and AgeAccel.Hannum. Similarly, epigenetic age acceleration increased by 0.15-0.81 years per SD increase in markers of vascular function (blood pressure, arterial stiffness, and hemodynamic measures), whereas better endothelial function was only associated with lower AgeAccelGrim. Most effects on epigenetic age acceleration were independent, which suggests they independently contribute to different rates of biological aging.

引用

页码：1605 / 1618

页数：14

共 60 条

[1] Measurement and Interpretation of the Ankle-Brachial Index A Scientific Statement From the American Heart Association [J].

Aboyans, Victor ;

Criqui, Michael H. ;

Abraham, Pierre ;

Allison, Matthew A. ;

Creager, Mark A. ;

Diehm, Curt ;

Fowkes, F. Gerry R. ;

Hiatt, William R. ;

Joensson, Bjoern ;

Lacroix, Philippe ;

Marin, Benoit ;

McDermott, Mary M. ;

Norgren, Lars ;

Pande, Reena L. ;

Preux, Pierre-Marie ;

Stoffers, H. E. ;

Treat-Jacobson, Diane .

CIRCULATION, 2012, 126 (24) :2890-+

[2] Glucose-induced, duration-dependent genome-wide DNA methylation changes in human endothelial cells [J].

Aref-Eshghi, Erfan ;

Biswas, Saumik ;

Chen, Charlie ;

Sadikovic, Bekim ;

Chakrabarti, Subrata .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2020, 319 (02) :C268-C276

[3] Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population [J].

Bell, Jordana T. ;

Tsai, Pei-Chien ;

Yang, Tsun-Po ;

Pidsley, Ruth ;

Nisbet, James ;

Glass, Daniel ;

Mangino, Massimo ;

Zhai, Guangju ;

Zhang, Feng ;

Valdes, Ana ;

Shin, So-Youn ;

Dempster, Emma L. ;

Murray, Robin M. ;

Grundberg, Elin ;

Hedman, Asa K. ;

Nica, Alexandra ;

Small, Kerrin S. ;

Dermitzakis, Emmanouil T. ;

McCarthy, Mark I. ;

Mill, Jonathan ;

Spector, Tim D. ;

Deloukas, Panos .

PLOS GENETICS, 2012, 8 (04) :189-200

[4] Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction An Individual Participant Meta-Analysis of Prospective Observational Data From 17,635 Subjects [J].

Ben-Shlomo, Yoav ;

Spears, Melissa ;

Boustred, Chris ;

May, Margaret ;

Anderson, Simon G. ;

Benjamin, Emelia J. ;

Boutouyrie, Pierre ;

Cameron, James ;

Chen, Chen-Huan ;

Cruickshank, J. Kennedy ;

Hwang, Shih-Jen ;

Lakatta, Edward G. ;

Laurent, Stephane ;

Maldonado, Joao ;

Mitchell, Gary F. ;

Najjar, Samer S. ;

Newman, Anne B. ;

Ohishi, Mitsuru ;

Pannier, Bruno ;

Pereira, Telmo ;

Vasan, Ramachandran S. ;

Shokawa, Tomoki ;

Sutton-Tyrell, Kim ;

Verbeke, Francis ;

Wang, Kang-Ling ;

Webb, David J. ;

Hansen, Tine Willum ;

Zoungas, Sophia ;

McEniery, Carmel M. ;

Cockcroft, John R. ;

Wilkinson, Ian B. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (07) :636-646

[5] Frailty is associated with the epigenetic clock but not with telomere length in a German cohort [J].

Breitling, Lutz Philipp ;

Saum, Kai-Uwe ;

Perna, Laura ;

Schoettker, Ben ;

Holleczek, Bernd ;

Brenner, Hermann .

CLINICAL EPIGENETICS, 2016, 8 :1-8

[6] DNA methylation-based measures of biological age: meta-analysis predicting time to death [J].

Chen, Brian H. ;

Marioni, Riccardo E. ;

Colicino, Elena ;

Peters, Marjolein J. ;

Ward-Caviness, Cavin K. ;

Tsai, Pei-Chien ;

Roetker, Nicholas S. ;

Just, Allan C. ;

Demerath, Ellen W. ;

Guan, Weihua ;

Bressler, Jan ;

Fornage, Myriam ;

Studenski, Stephanie ;

Vandiver, Amy R. ;

Moore, Ann Zenobia ;

Tanaka, Toshiko ;

Kiel, Douglas P. ;

Liang, Liming ;

Vokonas, Pantel ;

Schwartz, Joel ;

Lunetta, Kathryn L. ;

Murabito, Joanne M. ;

Bandinelli, Stefania ;

Hernandez, Dena G. ;

Melzer, David ;

Nalls, Michael ;

Pilling, Luke C. ;

Price, Timothy R. ;

Singleton, Andrew B. ;

Gieger, Christian ;

Holle, Rolf ;

Kretschmer, Anja ;

Kronenberg, Florian ;

Kunze, Sonja ;

Linseisen, Jakob ;

Meisinger, Christine ;

Rathmann, Wolfgang ;

Waldenberger, Melanie ;

Visscher, Peter M. ;

Shah, Sonia ;

Wray, Naomi R. ;

McRae, Allan F. ;

Franco, Oscar H. ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Absher, Devin ;

Assimes, Themistocles ;

Levine, Morgan E. ;

Lu, Ake T. ;

Tsao, Philip S. .

AGING-US, 2016, 8 (09) :1844-1865

[7] New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia [J].

Choi, Patricia J. ;

Brunt, Vienna E. ;

Fujii, Naoto ;

Minson, Christopher T. .

JOURNAL OF APPLIED PHYSIOLOGY, 2014, 117 (03) :277-283

[8] Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+study [J].

Collerton, Joanna ;

Martin-Ruiz, Carmen ;

Kenny, Antoinette ;

Barrass, Karen ;

von Zglinicki, Thomas ;

Kirkwood, Tom ;

Keavney, Bernard .

EUROPEAN HEART JOURNAL, 2007, 28 (02) :172-176

[9] General cardiovascular risk profile for use in primary care - The Framingham Heart Study [J].

D'Agostino, Ralph B. ;

Vasan, Ramachandran S. ;

Pencina, Michael J. ;

Wolf, Philip A. ;

Cobain, Mark ;

Massaro, Joseph M. ;

Kannel, William B. .

CIRCULATION, 2008, 117 (06) :743-753

[10] Blood lipids influence DNA methylation in circulating cells [J].

Dekkers, Koen F. ;

van Iterson, Maarten ;

Slieker, Roderick C. ;

Moed, Matthijs H. ;

Bonder, Marc Jan ;

van Galen, Michiel ;

Mei, Hailiang ;

Zhernakova, Daria V. ;

van den Berg, Leonard H. ;

Deelen, Joris ;

van Dongen, Jenny ;

van Heemst, Diana ;

Hofman, Albert ;

Hottenga, Jouke J. ;

van der Kallen, Carla J. H. ;

Schalkwijk, Casper G. ;

Stehouwer, Coen D. A. ;

Tigchelaar, Ettje F. ;

Uitterlinden, Andre G. ;

Willemsen, Gonneke ;

Zhernakova, Alexandra ;

Franke, Lude ;

't Hoen, Peter A. C. ;

Jansen, Rick ;

van Meurs, Joyce ;

Boomsma, Dorret I. ;

van Duijn, Cornelia M. ;

van Greevenbroek, Marleen M. J. ;

Veldink, Jan H. ;

Wijmenga, Cisca ;

van Zwet, Erik W. ;

Slagboom, P. Eline ;

Jukema, J. Wouter ;

Heijmans, Bastiaan T. .

GENOME BIOLOGY, 2016, 17

← 1 2 3 4 5 6 →