Tracers and Imaging of Fatty Acid and Energy Metabolism of Human Adipose Tissues

被引:6
作者
Carpentier, Andre C. [1 ]
机构
[1] Univ Sherbrooke, Ctr Hosp Univ Sherbrooke, Dept Med, Div Endocrinol,Ctr Derech, Sherbrooke, PQ, Canada
基金
加拿大健康研究院;
关键词
adipose tissue; brown adipose tissue; cardiometabolic diseases; positron emission tomography; tracer methods; POSITRON-EMISSION-TOMOGRAPHY; IMPAIRED GLUCOSE-TOLERANCE; SKELETAL-MUSCLE; OXIDATIVE-METABOLISM; CONSENSUS STATEMENT; MYOCARDIAL UPTAKE; LIPID TURNOVER; BROWN; LIVER; INSULIN;
D O I
10.1152/physiol.00012.2023
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
White adipose tissue and brown adipose tissue (WAT and BAT) regulate fatty acid metabolism and control lipid fluxes to other organs. Dysfunction of these key metabolic processes contributes to organ insulin resistance and inflammation leading to chronic diseases such as type 2 diabetes, metabolic dysfunction-associated steatohepatitis, and cardiovascular diseases. Metabolic tracers combined with molecular imaging methods are powerful tools for the investigation of these pathogenic mechanisms. Herein, I review some of the positron emission tomography and magnetic resonance imaging methods combined with stable isotopic metabolic tracers to investigate fatty acid and energy metabolism, focusing on human WAT and BAT metabolism. I will discuss the complementary strengths offered by these methods for human investigations and current gaps in the field.
引用
收藏
页码:61 / 72
页数:12
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