Allergic rhinitis and other comorbidities associated with asthma control in Thailand

被引：1

作者：

Sriprasart, Thitiwat ^{[1
]}

Saiphoklang, Narongkorn ^{[2
]}

Kawamatawong, Theerasuk ^{[3
]}

Boonsawat, Watchara ^{[4
]}

Mitthamsiri, Wat ^{[5
]}

Chirakalwasan, Naricha ^{[1
,6
]}

Chiewchalermsri, Chirawat ^{[7
]}

Athipongarporn, Athipat ^{[8
]}

Kamalaporn, Harutai ^{[9
]}

Kornthatchapong, Kumpol ^{[10
]}

Kulpraneet, Manaphol ^{[11
]}

Sompornrattanaphan, Mongkhon ^{[12
]}

Oer-Areemitr, Nittha ^{[13
]}

Rerkpattanapipat, Ticha ^{[14
]}

Silairatana, Santi ^{[15
]}

Thawanaphong, Sarita ^{[1
]}

Gaensan, Thanate ^{[16
]}

Jirakran, Ketsupar ^{[17
]}

Poachanukoon, Orapan ^{[18
]}

机构：

[1] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med,Thai Red Cross Soci, Dept Internal Med,Div Pulm & Crit Care Med, Bangkok, Thailand

[2] Thammasat Univ, Fac Med, Dept Internal Med, Div Pulm & Crit Care Med, Pathum Thani, Thailand

[3] Mahidol Univ, Ramathibodi Hosp, Fac Med, Div Pulm & Crit Care Med,Dept Internal Med, Bangkok, Thailand

[4] Khon Kaen Univ, Fac Med, Dept Med, Khon Kaen, Thailand

[5] Phramongkutklao Hosp, Dept Med, Allergy & Clin Immunol Div, Bangkok, Thailand

[6] Thai Red Cross Soc, Excellence Ctr Sleep Disorders, Bangkok, Thailand

[7] Srinakharinwirot Univ, Panyananthaphikkhu Chonprathan Med Ctr, Dept Med, Nonthaburi, Thailand

[8] Phra Nakhon Si Ayutthaya Hosp, Dept Pediat, Phra Nakhon Si Ayutthaya, Thailand

[9] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Pediat,Div Pediat Pulmonol, Bangkok, Thailand

[10] Thammasat Univ, Fac Med, Dept Emergency Med, Pathum Thani, Thailand

[11] Srinakharinwirot Univ, Div Pulm & Crit Care, Dept Med, Bangkok, Thailand

[12] Mahidol Univ, Fac Med, Dept Med, Div Allergy & Clin Immunol,Siriraj Hosp, Bangkok, Thailand

[13] Ekachai Hosp, Div Pulm & Crit Care Med, Samut Sakhon, Thailand

[14] Mahidol Univ, Ramathibodi Hosp, Fac Med, Allergy Immunol & Rheumatol Div,Dept Med, Bangkok, Thailand

[15] Navamindradhiraj Univ, Fac Med, Dept Med, Div Pulm Med & Pulm Crit Care,Vajira Hosp, Bangkok, Thailand

[16] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Family Med, Bangkok, Thailand

[17] Chulalongkorn Univ, Fac Med, Ctr Excellence Maximizing Childrens Dev Potential, Dept Pediat, Bangkok, Thailand

[18] Thammasat Univ, Ctr Excellence Allergy Asthma & Pulm Dis, Pathum Thani, Thailand

来源：

FRONTIERS IN MEDICINE | 2024年 / 10卷

关键词：

ACT; asthma; asthma control test; allergic rhinitis; comorbidities; IgE; quality of life; Thailand; QUALITY-OF-LIFE; GASTROESOPHAGEAL-REFLUX; LUNG-FUNCTION; IMPACT; PREVALENCE; VALIDATION; DEPRESSION; MANAGEMENT; CHILDREN; VALIDITY;

D O I：

10.3389/fmed.2023.1308390

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Asthma and allergic rhinitis (AR) can coexist and cause disabilities. This study aimed to assess the association between AR, asthma control, asthma-related quality of life, and other comorbidities. Methods: A cross-sectional study was conducted in adults with asthma in six hospitals in Thailand. The outcomes were association of asthma control assessed by the asthma control test (ACT), AR, and asthma comorbidities. Not-well-controlled asthma was defined as ACT scores <= 22. The severity of AR was determined by visual analog scale (VAS). Severe AR was defined as VAS >= 5. Asthma-related quality of life (AQLQ), comorbidities, and total IgE were recorded. Results: A total of 682 asthmatic patients were included. Median (IQR) age was 58.0 (47.0-64.0) years. 69.9% were female. Not-well-controlled asthma was present in 44.7%. The prevalence of AR was 86.1%. Moderate/severe persistent AR was diagnosed in 21.7% and severe AR was diagnosed in 30.2% of the patients. Inhaled corticosteroid-containing regimens were prescribed in 97.7% of patients. Intranasal corticosteroid and antihistamine were prescribed in 65.7 and 31.7%, respectively. Patients with not-well-controlled asthma had higher body mass index, VAS scores, proportions of pollution exposure, aeroallergen sensitization, severe AR, nasal polyp, urticaria, food allergy, gastroesophageal reflux disease, depression and anxiety, peptic ulcer, and asthma exacerbations, but younger age, lower AQLQ scores, and lower FEV1. Correlation was found between AR severity and ACT (r = -0.461, p < 0.001), AQLQ (r = -0.512, p < 0.001), and total IgE (r = 0.246, p < 0.023). Multiple regression analysis revealed that ACT, AQLQ, and percentage of FEV1/FVC were significantly associated with severe AR. Conclusion: Allergic rhinitis is prevalent in Thai asthmatic patients. AR severity is associated with asthma control, quality of life, and pulmonary function. Comprehensive care is essential for patients with uncontrolled asthma, particularly when coexisting with conditions.

引用

页数：10

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