Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review

被引：3

作者：

Doernberg, Sarah B. ^{[1
]}

Arias, Cesar A. ^{[2
,3
,4
]}

Altman, Deena R. ^{[5
,6
]}

Babiker, Ahmed ^{[7
,8
]}

Boucher, Helen W. ^{[9
]}

Creech, C. Buddy ^{[10
,11
]}

Cosgrove, Sara E. ^{[12
]}

Evans, Scott R. ^{[13
]}

Fowler Jr, Vance G. ^{[14
]}

Fritz, Stephanie A. ^{[15
]}

Hamasaki, Toshimitsu ^{[16
]}

Kelly, Brendan J. ^{[17
]}

Leal Jr, Sixto M. ^{[18
]}

Liu, Catherine ^{[19
,20
]}

Lodise, Thomas P. ^{[21
]}

Miller, Loren G. ^{[22
,23
]}

Munita, Jose M. ^{[24
,25
]}

Murray, Barbara E. ^{[26
]}

Pettigrew, Melinda M. ^{[27
]}

Ruffin, Felicia ^{[14
]}

Scheetz, Marc H. ^{[28
]}

Shopsin, Bo ^{[29
,30
]}

Tran, Truc T. ^{[3
]}

Turner, Nicholas A. ^{[14
]}

Williams, Derek J. ^{[31
,32
]}

Zaharoff, Smitha ^{[33
]}

Holland, Thomas L. ^{[14
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Infect Dis, San Francisco, CA USA

[2] Houston Methodist Hosp, Div Infect Dis, Dept Med, Houston, TX USA

[3] Houston Methodist Res Inst, Ctr Infect Dis, Houston, TX USA

[4] Weill Cornell Med Coll, Dept Med, New York, NY USA

[5] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY USA

[6] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

[7] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA

[8] Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA USA

[9] Tufts Univ, Sch Med, Medford, MA USA

[10] Vanderbilt Univ, Sch Med, Dept Pediat, Div Pediat Infect Dis, Nashville, TN 37212 USA

[11] Vanderbilt Univ, Med Ctr, Vanderbilt Vaccine Res Program, Nashville, TN USA

[12] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA

[13] George Washington Univ, Dept Biostat, Washington, DC USA

[14] Duke Univ, Sch Med, Dept Med, Div Infect Dis, Durham, NC USA

[15] Washington Univ, Dept Med, Div Infect Dis, Sch Med, St Louis, MO USA

[16] George Washington Univ, Biostat Ctr, Rockville, MD USA

[17] Univ Penn, Perelman Sch Med, Dept Med, Div Infect Dis, Philadelphia, PA USA

[18] Univ Alabama Birmingham, Dept Lab Med, Birmingham, AL USA

[19] Fred Hutchinson Canc Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[20] Univ Washington, Div Allergy & Infect Dis, Seattle, WA 98195 USA

[21] Albany Coll Pharm & Hlth Sci, Dept Pharm Practice, Albany, NY USA

[22] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA

[23] Harbor UCLA Med Ctr, Lundquist Inst, Div Infect Dis, Torrance, CA USA

[24] Univ Desarrollo, Fac Med Clin Alemana, Inst Ciencias & Innovac Med, Santiago, Chile

[25] Multidisciplinary Initiat Collaborat Res Bacteria, Santiago, Chile

[26] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Internal Med, Div Infect Dis, Houston, TX USA

[27] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA

[28] Midwestern Univ, Coll Pharm, Pharmacometr Ctr Excellence, Downers Grove, IL USA

[29] NYU, Dept Med, Div Infect Dis, Grossman Sch Med, New York, NY USA

[30] NYU, Dept Microbiol, Grossman Sch Med, New York, NY USA

[31] Vanderbilt Univ, Div Hosp Med, Sch Med, Dept Pediat, Nashville, TN USA

[32] Vanderbilt Univ, Monroe Carell Jr Childrens Hosp, Med Ctr, Nashville, TN USA

[33] Duke Univ, Duke Clin Res Inst, Sch Med, Durham, NC 27710 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 77卷 / SUPP4期

基金：

美国国家卫生研究院;

关键词：

antibacterial resistance; gram-positive bacterial infections; antibacterial agents; methicillin-resistant Staphylococcus aureus; vancomycin-resistant enterococci; STAPHYLOCOCCUS-AUREUS INFECTIONS; ONCE-WEEKLY DALBAVANCIN; CARE-ASSOCIATED INFECTIONS; DIFFICILE INFECTION; DISEASES SOCIETY; VANCOMYCIN; THERAPY; SKIN; SAFETY; RISK;

D O I：

10.1093/cid/ciad565

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections. The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its scientific priority areas. This article describes accomplishments and future directions of ARLG gram-positive studies.

引用

页码：S295 / S304

页数：10

共 64 条

[41] Bloodstream Infection Due to Vancomycin-resistant Enterococcus Is Associated With Increased Mortality After Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndrome: A Multicenter, Retrospective Cohort Study [J].

Papanicolaou, Genovefa A. ;

Ustun, Celalettin ;

Young, Jo-Anne H. ;

Chen, Min ;

Kim, Soyoung ;

Ahn, Kwang Woo ;

Komanduri, Krishna ;

Lindemans, Caroline ;

Auletta, Jeffery J. ;

Riches, Marcie L. ;

Abdel-Azim, Hisham ;

Ahmed, Ibrahim A. ;

Aljurf, Mahmoud ;

Antin, Joseph ;

Ballen, Karen Kuhn ;

Beitinjaneh, Amer ;

Brown, Valerie I. ;

Cerny, Jan ;

Champlin, Richard ;

Chao, Nelson ;

Chhabra, Saurabh ;

Dahi, Parastoo B. ;

Daly, Andrew ;

Dandoy, Christopher ;

Dvorak, Christopher C. ;

Forman, Stephen ;

Freytes, Cesar ;

Ganguly, Siddhartha ;

Hashmi, Shahrukh K. ;

Kharfan-Dabaja, Mohamed A. ;

Lazarus, Hillard ;

Ljungman, Per ;

Malone, Adriana K. ;

Murthy, Guru ;

Nishihori, Taiga ;

Page, Kristin ;

Pingali, Ravi ;

Reddy, Vijay ;

Saad, Ayman ;

Savani, Bipin N. ;

Seftel, Matthew ;

Szer, Jeffrey ;

Vij, Ravi ;

Weisdorf, Daniel ;

William, Basem M. ;

Williams, Kirsten ;

Wirk, Baldeep ;

Yared, Jean ;

Yu, Lolie C. .

CLINICAL INFECTIOUS DISEASES, 2019, 69 (10) :1771-1779

[42] Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia [J].

Pettigrew, M. M. ;

Kwon, J. ;

Gent, J. F. ;

Kong, Y. ;

Wade, M. ;

Williams, D. J. ;

Creech, C. B. ;

Evans, S. ;

Pan, Q. ;

Walter, E. B. ;

Martin, J. M. ;

Gerber, J. S. ;

Newland, J. G. ;

Hofto, M. E. ;

Staat, M. A. ;

Fowler, V. G. ;

Chambers, H. F. ;

Huskins, W. C. .

MBIO, 2022, 13 (02)

[43] Overdiagnosis of Clostridium difficile Infection in the Molecular Test Era [J].

Polage, Christopher R. ;

Gyorke, Clare E. ;

Kennedy, Michael A. ;

Leslie, Jhansi L. ;

Chin, David L. ;

Wang, Susan ;

Nguyen, Hien H. ;

Huang, Bin ;

Tang, Yi-Wei ;

Lee, Lenora W. ;

Kim, Kyoungmi ;

Taylor, Sandra ;

Romano, Patrick S. ;

Panacek, Edward A. ;

Goodell, Parker B. ;

Solnick, Jay V. ;

Cohen, Stuart H. .

JAMA INTERNAL MEDICINE, 2015, 175 (11) :1792-1801

[44] VRE and VSE Bacteremia Outcomes in the Era of Effective VRE Therapy: A Systematic Review and Meta-analysis [J].

Prematunge, Chatura ;

MacDougall, Colin ;

Johnstone, Jennie ;

Adomako, Kwaku ;

Lam, Freda ;

Robertson, Jennifer ;

Garber, Gary .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2016, 37 (01) :26-35

[45] Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogens [J].

Raad, I ;

Darouiche, R ;

Vazquez, J ;

Lentnek, A ;

Hachem, R ;

Hanna, H ;

Goldstein, B ;

Henkel, T ;

Seltzer, E .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (03) :374-380

[46] The maxwell Finland lecture:: For the duration -: Rational antibiotic administration in an era of antimicrobial resistance and Clostridium difficile [J].

Rice, Louis B. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (04) :491-496

[47] Therapeutic monitoring of vancomycin for serious -methicillin-resistant Staphylococcus aureus infections: A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists [J].

Rybak, Michael J. ;

Le, Jennifer ;

Lodise, Thomas P. ;

Levine, Donald P. ;

Bradley, John S. ;

Liu, Catherine ;

Mueller, Bruce A. ;

Pai, Manjunath P. ;

Wong-Beringer, Annie ;

Rotschafer, John C. ;

Rodvold, Keith A. ;

Maples, Holly D. ;

Lomaestro, Benjamin M. .

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2020, 77 (11) :835-863

[48] Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships [J].

Scheetz, Marc H. ;

Pais, Gwendolyn M. ;

Lodise, Thomas P. ;

Tong, Steven Y. C. ;

Davis, Joshua S. ;

O'Donnell, J. Nicholas ;

Liu, Jiajun ;

Neely, Michael ;

Prozialeck, Walter C. ;

Lamar, Peter C. ;

Rhodes, Nathaniel J. ;

Holland, Thomas ;

Avedissian, Sean N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (10)

[49] Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections [J].

Seltzer, E ;

Dorr, MB ;

Goldstein, BP ;

Perry, M ;

Dowell, JA ;

Henkel, T .

CLINICAL INFECTIOUS DISEASES, 2003, 37 (10) :1298-1303

[50] Applying the Infectious Diseases Literature to People who Inject Drugs [J].

Serota, David P. ;

Chueng, Teresa A. ;

Schechter, Marcos C. .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2020, 34 (03) :539-+

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