Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review

被引：3

作者：

Doernberg, Sarah B. ^{[1
]}

Arias, Cesar A. ^{[2
,3
,4
]}

Altman, Deena R. ^{[5
,6
]}

Babiker, Ahmed ^{[7
,8
]}

Boucher, Helen W. ^{[9
]}

Creech, C. Buddy ^{[10
,11
]}

Cosgrove, Sara E. ^{[12
]}

Evans, Scott R. ^{[13
]}

Fowler Jr, Vance G. ^{[14
]}

Fritz, Stephanie A. ^{[15
]}

Hamasaki, Toshimitsu ^{[16
]}

Kelly, Brendan J. ^{[17
]}

Leal Jr, Sixto M. ^{[18
]}

Liu, Catherine ^{[19
,20
]}

Lodise, Thomas P. ^{[21
]}

Miller, Loren G. ^{[22
,23
]}

Munita, Jose M. ^{[24
,25
]}

Murray, Barbara E. ^{[26
]}

Pettigrew, Melinda M. ^{[27
]}

Ruffin, Felicia ^{[14
]}

Scheetz, Marc H. ^{[28
]}

Shopsin, Bo ^{[29
,30
]}

Tran, Truc T. ^{[3
]}

Turner, Nicholas A. ^{[14
]}

Williams, Derek J. ^{[31
,32
]}

Zaharoff, Smitha ^{[33
]}

Holland, Thomas L. ^{[14
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Infect Dis, San Francisco, CA USA

[2] Houston Methodist Hosp, Div Infect Dis, Dept Med, Houston, TX USA

[3] Houston Methodist Res Inst, Ctr Infect Dis, Houston, TX USA

[4] Weill Cornell Med Coll, Dept Med, New York, NY USA

[5] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY USA

[6] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA

[7] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA

[8] Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA USA

[9] Tufts Univ, Sch Med, Medford, MA USA

[10] Vanderbilt Univ, Sch Med, Dept Pediat, Div Pediat Infect Dis, Nashville, TN 37212 USA

[11] Vanderbilt Univ, Med Ctr, Vanderbilt Vaccine Res Program, Nashville, TN USA

[12] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD USA

[13] George Washington Univ, Dept Biostat, Washington, DC USA

[14] Duke Univ, Sch Med, Dept Med, Div Infect Dis, Durham, NC USA

[15] Washington Univ, Dept Med, Div Infect Dis, Sch Med, St Louis, MO USA

[16] George Washington Univ, Biostat Ctr, Rockville, MD USA

[17] Univ Penn, Perelman Sch Med, Dept Med, Div Infect Dis, Philadelphia, PA USA

[18] Univ Alabama Birmingham, Dept Lab Med, Birmingham, AL USA

[19] Fred Hutchinson Canc Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[20] Univ Washington, Div Allergy & Infect Dis, Seattle, WA 98195 USA

[21] Albany Coll Pharm & Hlth Sci, Dept Pharm Practice, Albany, NY USA

[22] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA

[23] Harbor UCLA Med Ctr, Lundquist Inst, Div Infect Dis, Torrance, CA USA

[24] Univ Desarrollo, Fac Med Clin Alemana, Inst Ciencias & Innovac Med, Santiago, Chile

[25] Multidisciplinary Initiat Collaborat Res Bacteria, Santiago, Chile

[26] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Internal Med, Div Infect Dis, Houston, TX USA

[27] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA

[28] Midwestern Univ, Coll Pharm, Pharmacometr Ctr Excellence, Downers Grove, IL USA

[29] NYU, Dept Med, Div Infect Dis, Grossman Sch Med, New York, NY USA

[30] NYU, Dept Microbiol, Grossman Sch Med, New York, NY USA

[31] Vanderbilt Univ, Div Hosp Med, Sch Med, Dept Pediat, Nashville, TN USA

[32] Vanderbilt Univ, Monroe Carell Jr Childrens Hosp, Med Ctr, Nashville, TN USA

[33] Duke Univ, Duke Clin Res Inst, Sch Med, Durham, NC 27710 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 77卷 / SUPP4期

基金：

美国国家卫生研究院;

关键词：

antibacterial resistance; gram-positive bacterial infections; antibacterial agents; methicillin-resistant Staphylococcus aureus; vancomycin-resistant enterococci; STAPHYLOCOCCUS-AUREUS INFECTIONS; ONCE-WEEKLY DALBAVANCIN; CARE-ASSOCIATED INFECTIONS; DIFFICILE INFECTION; DISEASES SOCIETY; VANCOMYCIN; THERAPY; SKIN; SAFETY; RISK;

D O I：

10.1093/cid/ciad565

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections. The Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its scientific priority areas. This article describes accomplishments and future directions of ARLG gram-positive studies.

引用

页码：S295 / S304

页数：10

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