Design of layer-by-layer lipid-polymer hybrid nanoparticles to elicit oral bioavailability of buspirone hydrochloride

被引：4
作者：
Dangre, Pankaj [1 ,2 ]
Sonawane, Kajal [2 ]
Moravkar, Kailas [2 ]
Pethe, Anil [1 ]
Chalikwar, Shailesh [2 ]
Borse, Vivek [3 ]
机构：
[1] DMIHER DU, Datta Meghe Coll Pharm, Dept Pharmaceut, Wardha, India
[2] RC Patel Inst Pharmaceut Educ & Res, Dept Ind Pharm & Pharmaceut Qual Assurance, Shirpur, India
[3] Natl Inst Pharmaceut Educ & Res, Dept Med Devices, NanoBioSens Lab, Hyderabad, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 13期
关键词：
Layer-by-layer; buspirone HCl; hybrid nanoparticles; polyelectrolytes multilayer; high-pressure homogenization; STATISTICAL OPTIMIZATION; CONTROLLED DELIVERY; FORMULATION; EFFICACY;
D O I：
10.1080/00914037.2023.2255720
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 +/- 4.2nm and zeta potential of -30.5 +/- 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates. [GRAPHICS]
引用
收藏
页码：1185 / 1195
页数：11
相关论文
共 34 条
[11]   Fabrication of hesperidin self-micro-emulsifying nutraceutical delivery system embedded in sodium alginate beads to elicit gastric stability [J].
Dangre, Pankaj, V ;
Dusad, Poorva P. ;
Singh, Alok D. ;
Surana, Sanjay J. ;
Chaturvedi, Kaushalendra K. ;
Chalikwar, Shailesh S. .
POLYMER BULLETIN, 2022, 79 (01) :605-626
[12]   Development and statistical optimization of alginate-Neusilin US2 micro-composite beads to elicit gastric stability and sustained action of hesperidin [J].
Dangre, Pankaj, V ;
Tattu, Avinash D. ;
Borikar, Sachin P. ;
Surana, Sanjay J. ;
Chalikwar, Shailesh S. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 171 :514-526
[13]   Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system [J].
Dave, Vivek ;
Yadav, Renu Bala ;
Kushwaha, Kriti ;
Yadav, Sachdev ;
Sharma, Swapnil ;
Agrawal, Udita .
BIOACTIVE MATERIALS, 2017, 2 (04) :269-280
[14]   Pharmacodynamic, pharmacokinetic and physical characterization of cilnidipine loaded solid lipid nanoparticles for oral delivery optimized using the principles of design of experiments [J].
Diwan, Rimpy ;
Ravi, Punna Rao ;
Pathare, Nikita Shantaram ;
Aggarwal, Vidushi .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2020, 193
[15]   Polymer-lipid hybrid nanoparticles: A novel drug delivery system for enhancing the activity of Psoralen against breast cancer [J].
Du, Manling ;
Ouyang, Yong ;
Meng, Fansu ;
Zhang, Xingwang ;
Ma, Qianqian ;
Zhuang, Yong ;
Liu, Hui ;
Pang, Mujuan ;
Cai, Tiange ;
Cai, Yu .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 561 :274-282
[16]   Review of hybrid PLGA nanoparticles: Future of smart drug delivery and theranostics medicine [J].
Ghitman, Jana ;
Biru, Elena Iuliana ;
Stan, Raluca ;
Iovu, Horia .
MATERIALS & DESIGN, 2020, 193
[17]   Development of ritonavir-loaded nanostructured lipid carriers employing quality by design (QbD) as a tool: characterizations, permeability, and bioavailability studies [J].
Gurumukhi, Vishal C. ;
Bari, Sanjaykumar B. .
DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2022, 12 (07) :1753-1773
[18]   Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid) [J].
Heredia, Nathaly S. ;
Vizuete, Karla ;
Flores-Calero, Marco ;
Pazmino, Katherine, V ;
Pilaquinga, Fernanda ;
Kumar, Brajesh ;
Debut, Alexis .
PLOS ONE, 2022, 17 (03)
[19]   Lipid-chitosan hybrid nanoparticles for controlled delivery of cisplatin [J].
Khan, Muhammad Muzamil ;
Madni, Asadullah ;
Torchilin, Vladimir ;
Filipczak, Nina ;
Pan, Jiayi ;
Tahir, Nayab ;
Shah, Hassan .
DRUG DELIVERY, 2019, 26 (01) :765-772
[20]   Development of HPLC Method for the Determination of Buspirone in Rat Plasma Using Fluorescence Detection and Its Application to a Pharmacokinetic Study [J].
Kim, Ki Taek ;
Lee, Jae-Young ;
Park, Ju-Hwan ;
Kim, Min Hwan ;
Kim, Ji-Su ;
Shin, Hyeon-Jong ;
Kang, Naewon ;
Cho, Hyun-Jong ;
Yoon, In-Soo ;
Kim, Dae-Duk .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 64 (11) :1582-1588
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