Design of layer-by-layer lipid-polymer hybrid nanoparticles to elicit oral bioavailability of buspirone hydrochloride

被引：4
作者：
Dangre, Pankaj [1 ,2 ]
Sonawane, Kajal [2 ]
Moravkar, Kailas [2 ]
Pethe, Anil [1 ]
Chalikwar, Shailesh [2 ]
Borse, Vivek [3 ]
机构：
[1] DMIHER DU, Datta Meghe Coll Pharm, Dept Pharmaceut, Wardha, India
[2] RC Patel Inst Pharmaceut Educ & Res, Dept Ind Pharm & Pharmaceut Qual Assurance, Shirpur, India
[3] Natl Inst Pharmaceut Educ & Res, Dept Med Devices, NanoBioSens Lab, Hyderabad, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 13期
关键词：
Layer-by-layer; buspirone HCl; hybrid nanoparticles; polyelectrolytes multilayer; high-pressure homogenization; STATISTICAL OPTIMIZATION; CONTROLLED DELIVERY; FORMULATION; EFFICACY;
D O I：
10.1080/00914037.2023.2255720
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 +/- 4.2nm and zeta potential of -30.5 +/- 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates. [GRAPHICS]
引用
收藏
页码：1185 / 1195
页数：11
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