Melanomas in children and adolescents: Clinicopathologic features and survival outcomes

被引：9

作者：

El Sharouni, Mary-Ann ^{[1
,2
]}

Rawson, Robert, V ^{[1
,3
,4
,5
]}

Potter, Alison J. ^{[1
,3
,4
,5
]}

Paver, Elizabeth C. ^{[1
,3
,4
,5
]}

Wilmott, James S. ^{[1
,3
,6
]}

Witkamp, Arjen J. ^{[7
]}

Sigurdsson, Vigfus ^{[2
]}

van Diest, Paul J. ^{[8
]}

Scolyer, Richard A. ^{[1
,3
,4
,5
,6
]}

Thompson, John F. ^{[1
,3
,9
,11
]}

Lo, Serigne N. ^{[1
,3
]}

van Gils, Carla H. ^{[10
]}

机构：

[1] Univ Sydney, Melanoma Inst Australia, Sydney, NSW, Australia

[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Dermatol, Utrecht, Netherlands

[3] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia

[4] Royal Prince Alfred Hosp, Dept Tissue Oncol & Diagnost Pathol, Sydney, NSW, Australia

[5] NSW Hlth Pathol, Sydney, NSW, Australia

[6] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia

[7] Univ Utrecht, Univ Med Ctr Utrecht, Dept Surg, Utrecht, Netherlands

[8] Univ Utrecht, Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands

[9] Royal Prince Alfred Hosp, Dept Melanoma & Surg Oncol, Camperdown, NSW, Australia

[10] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[11] Melanoma Inst Australia, 40 Rocklands Rd, North Sydney, NSW 2060, Australia

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2023年 / 88卷 / 03期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Key words; adolescence; age; children; melanoma; survival; PEDIATRIC MELANOMA; MALIGNANT-MELANOMA; UNITED-STATES; CHILDHOOD; EPIDEMIOLOGY;

D O I：

10.1016/j.jaad.2022.08.067

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Melanomas in the first 2 decades of life are uncommon and poorly understood.Objective: To assess clinicopathologic features and survival of children (#11 years) and adolescents (12-19 years) diagnosed with melanoma.Methods: A pooled cohort of 514 patients was analyzed (397 Dutch, 117 Australian; 62 children, 452 adolescents). Pathology reports were reevaluated to determine melanoma subtypes. Multivariable Cox models were generated for recurrence-free survival (RFS) and overall survival (OS).Results: Melanoma subtypes were conventional melanoma (superficial spreading, nodular, desmoplastic, and acral lentiginous), spitzoid melanoma, and melanoma associated with a congenital nevus in 428, 78, and 8 patients, respectively. Ten-year RFS was 91.5% (95% confidence interval [CI], 82.4%-100%) in children and 86.4% (95% CI, 82.7%-90.3%) in adolescents (P = .32). Ten-year OS was 100% in children and 92.7% (95% CI, 89.8%-95.8%) in adolescents (P = .09). On multivariable analysis possible only for the adolescent cohort due to the small number of children, ulceration status, and anatomic site were associated with RFS and OS, whereas age, sex, mitotic index, sentinel node status and melanoma subtype were not. Breslow thickness [4 mm was associated with worse RFS.Limitations: Retrospective study.

引用

页码：609 / 616

页数：8

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