Challenging Metastatic Melanoma to the Lung With p40 Expression: A Diagnostic Pitfall, Case Report

被引：0

作者：

Thierry, Sixte ^{[1
]}

Juberthie, Bernard ^{[1
]}

Gyenes, Cezar ^{[1
]}

Dramais-Marcel, Dominique ^{[2
]}

Forest, Fabien ^{[3
,4
,5
]}

机构：

[1] Hosp Valence, Dept Pathol, Valence, France

[2] Hosp Valence, Dept Oncol, Valence, France

[3] Dept Pathol, Ave Albert Raimond, St Etienne, France

[4] Univ Hosp St Etienne, North Hosp, Unit Mol Biol Tumors, Ave Albert Raimond, St Etienne, France

[5] CHU St Etienne, Hop Nord, Serv Anat & Cytol Pathol, Ave Albert Raimond, F-42055 St Etienne 2, France

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2023年 / 31卷 / 01期

关键词：

p40; melanoma; squamous cell carcinoma; BRAF; DIFFERENTIAL-DIAGNOSIS; NUT CARCINOMA; P63; DELTA-NP63; MARKERS; TUMORS; ISOFORM;

D O I：

10.1097/PAI.0000000000001083

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

p40 immunohistochemistry is a cornerstone of histopathological examination for non-small cell lung carcinoma. p40 is an isoform of p63 and is reported to be highly specific for the diagnosis of squamous cell carcinoma. Very rare pitfalls are reported for this antibody, and p40 is typically negative in melanoma. A 66-year-old patient was admitted for multiple hemorrhagic brain tumors evocative of secondary tumors. On imaging, a 26 mm lung tumor was detected, and a biopsy of the lung tumor was performed. The tumor was stained by melanic markers and diffusely stained by p40 and p63. Molecular analysis found a somatic p.Asn581Ser (c.1742A>G) point mutation in exon 15 of BRAF and a p.Arg80Ter (c.238C>T) germline variant of CDKN2A, a predisposing mutation to melanoma. This case report highlights the importance of clinical, pathologic, and molecular correlation.

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页码：64 / 67

页数：4

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