Cytosporones with Anti-Inflammatory Activities from the Mangrove Endophytic Fungus Phomopsis sp. QYM-13

被引：4
作者：
Wang, Guisheng [1 ,2 ]
Yuan, Yilin [3 ]
Li, Zhaokun [1 ]
Zhu, Junhao [1 ]
She, Zhigang [2 ]
Chen, Yan [1 ]
机构：
[1] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China
[3] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China
来源：
MARINE DRUGS | 2023年 / 21卷 / 12期
基金：
中国国家自然科学基金;
关键词：
mangrove endophytic fungus; Phomopsis sp; cytosporone; anti-inflammatory; STRUCTURAL REVISION; DERIVATIVES;
D O I：
10.3390/md21120631
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six previously undescribed cytosporone derivatives (phomotones A-E (1-5) and phomotone F (13)), two new spiro-alkanol phombistenes A-B (14-15), and seven known analogs (6-12) were isolated from the mangrove endophytic fungus Phomopsis sp. QYM-13. The structures of these compounds were elucidated using spectroscopic data analysis, electronic circular dichroism (ECD), and C-13 NMR calculations. Compound 14 features an unprecedented 1,6-dioxaspiro[4.5]decane ring system. All isolates were evaluated for their inhibitory effect on nitric oxide (NO) in LPS-induced RAW264.7 cells. The results showed that compounds 1, 6, 8, and 11 exhibited potent bioactivities by comparing with positive control. Then, compound 1 displayed the anti-inflammatory effect by inhibiting the MAPK/NF-kappa B signaling pathways. Molecular docking further revealed the possible mechanism of compound 1 interaction with ERK protein.
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页数：12
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