NHC-Catalyzed Tandem Reaction: A Strategy for the Synthesis of 2-Pyrrolidinone-Functionalized Phenanthridines

被引：7

作者：

Zhou, Nengneng ^{[1
]}

Wang, Lei ^{[1
]}

Zhao, Fangli ^{[1
]}

Gao, Xiang ^{[1
]}

Zhao, Xiaowei ^{[1
]}

Zhang, Man ^{[1
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Key Lab Functionalized Mol Solids, Minist Educ,Anhui Key Lab Mol Based Mat, Wuhu 241000, Anhui, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 23期

基金：

中国国家自然科学基金;

关键词：

RADICAL C-P; 6-PHOSPHORYLATED PHENANTHRIDINES; METAL-FREE; CYCLIZATION; 2-ISOCYANOBIPHENYLS; ISOCYANIDES; DERIVATIVES; BASE;

D O I：

10.1021/acs.joc.3c02086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, an N-heterocyclic carbene (NHC)-catalyzed tandem cyclization/addition/cyclization reaction of 2-isocyanobiaryls and alpha-bromo-N-cinnamylamides for the synthesis of 2-pyrrolidinone-functionalized phenanthridines is developed. This protocol features a radical cascade process, broad substrate scope, and good functional group compatibility under metal- and oxidant-free reaction conditions.

引用

页码：16556 / 16565

页数：10

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