New approach to testing treatments for osteoarthritis: FastOA

被引：8

作者：

Felson, David ^{[1
,6
]}

Lotz, Martin K. ^{[2
]}

Jin, Yuxuan ^{[3
]}

Jones, Morgan ^{[4
]}

Kim, Jason S. ^{[5
]}

Spindler, Kurt ^{[3
]}

机构：

[1] Boston Univ, Sch Med, Boston, MA USA

[2] Scripps Res Inst, Mol & Expt Med, La Jolla, CA USA

[3] Cleveland Clin Fdn, Cleveland, OH USA

[4] Brigham & Womens Hosp, Boston, MA USA

[5] Arthritis Fdn, Atlanta, GA USA

[6] Boston Univ, Sch Med, Boston, MA 02118 USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2024年 / 83卷 / 03期

关键词：

Osteoarthritis; Orthopedic Procedures; Therapeutics; ACL RECONSTRUCTION; OUTCOMES; MOON; SURGERY; RISK;

D O I：

10.1136/ard-2023-224675

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Animal models of post traumatic osteoarthritis have shown many promising treatments for disease, but human trials have mostly failed to identify effective treatments. This viewpoint suggests that the frequent failure of drug and treatment development in osteoarthritis is due, in part, to the advanced stage of disease of patients in trials and suggests that mirroring the animal model approach might be more successful. It suggests a path forward by enriching trial enrollees with those likely to develop post traumatic OA quickly.

引用

页码：274 / 276

页数：3

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