Characterization of in vitro Metabolites of Methylenedioxy Designer Drugs

被引：0
作者：
Yu, Jun Sang [1 ,2 ,3 ]
Jo, So Young [1 ,2 ]
Park, Il-Ho [4 ]
Yoo, Hye Hyun [1 ,2 ]
机构：
[1] Hanyang Univ, Inst Pharmaceut Sci & Technol, Ansan 15588, Gyeonggi Do, South Korea
[2] Hanyang Univ, Coll Pharm, Ansan 15588, Gyeonggi Do, South Korea
[3] Hanyang Univ, Res Inst Engn & Technol, Ansan 15588, Gyeonggi, South Korea
[4] Sahmyook Univ, Coll Pharm, 815 Hwarang-ro, Seoul 01795, South Korea
来源：
MASS SPECTROMETRY LETTERS | 2023年 / 14卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Methylenedioxy derivatives; Designer drug; Metabolism; LC; Q-TOF MS; PHASE-I; IDENTIFICATION; 3,4-(METHYLENEDIOXY)METHAMPHETAMINE; PHARMACOLOGY; CONSTITUENT; MEPHEDRONE; MDPV;
D O I：
10.5478/MSL.2023.14.1.1
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
: Eutylone, dibutylone, and dimethylone are potential psychotropic designer drugs. The purpose of this study was to investigate the in vitro metabolic pathways of synthetic cathinones with methylenedioxy groups. The three methylenedioxy derivatives were incubated with human liver microsomes. The metabolites were characterized based on liquid chromatography and quadrupole-time-of-flight mass spectrometry. Eutylone, dibutylone, and dimethylone were metabolized to yield three, six, and four metabolites, respectively. Reduction and demethylenation were the major metabolic pathways for all three drugs tested. However, dibutylone and dimethylone showed an additional metabolite generated via N-oxidation. These results provide evi-dence for the in vivo metabolism of methylenedioxy synthetic cathinones, and could be applied to the analysis of synthetic cathi-nones and their relevant metabolites in biological samples.
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页码：1 / 8
页数：8
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