Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine

被引：22

作者：

Tauzin, Alexandra ^{[1
,2
]}

Nicolas, Alexandre ^{[1
,2
]}

Ding, Shilei ^{[1
]}

Benlarbi, Mehdi ^{[1
,2
]}

Medjahed, Halima ^{[1
]}

Chatterjee, Debashree ^{[1
]}

Dionne, Katrina ^{[1
,2
]}

Gong, Shang Yu ^{[1
,3
]}

Gendron-Lepage, Gabrielle ^{[1
]}

Bo, Yuxia ^{[1
,4
]}

Perreault, Josee ^{[5
]}

Goyette, Guillaume ^{[1
]}

Gokool, Laurie ^{[1
]}

Arlotto, Pascale ^{[1
]}

Morrisseau, Chantal ^{[1
]}

Tremblay, Cecile ^{[1
,2
]}

Martel-Laferriere, Valeri ^{[1
,2
,3
,4
,5
,6
,7
]}

De Serres, Gaston ^{[6
]}

Levade, Ines ^{[7
]}

Kaufmann, Daniel E. ^{[1
,8
,9
,10
]}

Cote, Marceline ^{[4
]}

Bazin, Renee ^{[5
]}

Finzi, Andres ^{[1
,2
,3
]}

机构：

[1] Ctr Rech CHUM, Montreal, PQ H2X 0A9, Canada

[2] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ H2X 0A9, Canada

[3] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada

[4] Univ Ottawa, Ctr Infect, Dept Biochem, Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[5] Hema Quebec Affaires Med & Innovat, Quebec City, PQ G1V 5C3, Canada

[6] Inst Natl Sante Publ Quebec, Quebec City, PQ H2P 1E2, Canada

[7] Inst Natl St Publ Quebec, Lab St Publ Quebec, Sainte Anne De Bellevue, PQ H9X 3R5, Canada

[8] Univ Montreal, Dept Medecine, Montreal, PQ H3T 1J4, Canada

[9] Univ Hosp Lausanne, Dept Med, Div Infect Dis, CH-1011 Lausanne, Switzerland

[10] Univ Lausanne, CH-1011 Lausanne, Switzerland

来源：

CELL REPORTS | 2023年 / 42卷 / 01期

基金：

芬兰科学院; 加拿大创新基金会;

关键词：

B cell responses; coronavirus; COVID-19; CP: Immunology; humoral responses; hybrid immunity; neutralization; Omicron subvariants; SARS-CoV-2; spike glycoproteins; third mRNA vaccine dose;

D O I：

10.1016/j.celrep.2023.111998

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have recently emerged, becoming the dominant circulating strains in many countries. These variants contain a large num-ber of mutations in their spike glycoprotein, raising concerns about vaccine efficacy. In this study, we eval-uate the ability of plasma from a cohort of individuals that received three doses of mRNA vaccine to recognize and neutralize these Omicron subvariant spikes. We observed that BA.4/5 and BQ.1.1 spikes are markedly less recognized and neutralized compared with the D614G and other Omicron subvariant spikes tested. Also, individuals who have been infected before or after vaccination present better humoral responses than SARS-CoV-2-naive vaccinated individuals, thus indicating that hybrid immunity generates better hu-moral responses against these subvariants.

引用

页数：15

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