Effectiveness of Vaccines and Antiviral Drugs in Preventing Severe and Fatal COVID-19, Hong Kong

被引：11

作者：

Cheung, Yue Yat Harrison ^{[1
]}

Lau, Eric Ho Yin ^{[1
,2
]}

Yin, Guosheng ^{[1
,3
]}

Lin, Yun ^{[1
]}

Cowling, Benjamin J. ^{[1
,2
]}

Lam, Kwok Fai ^{[1
,4
,5
]}

机构：

[1] Univ Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Sci & Technol Pk, Hong Kong, Peoples R China

[3] Imperial Coll London, London, England

[4] Duke NUS Med Sch, Singapore, Singapore

[5] Univ Hong Kong, Dept Stat & Actuarial Sci, Pokfulam Rd, Hong Kong, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2024年 / 30卷 / 01期

关键词：

NIRMATRELVIR-RITONAVIR; HOSPITAL ADMISSIONS; MORTALITY;

D O I：

10.3201/eid3001.230414

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared the effectiveness and interactions of molnupiravir and nirmatrelvir/ritonavir and 2 vaccines, CoronaVac and Comirnaty, in a large population of inpatients with COVID-19 in Hong Kong. Both the oral antiviral drugs and vaccines were associated with lower risks for all-cause mortality and progression to serious/ critical/fatal conditions (study outcomes). No significant interaction effects were observed between the antiviral drugs and vaccinations; their joint effects were additive. If antiviral drugs were prescribed within 5 days of confirmed COVID-19 diagnosis, usage was associated with lower risks for the target outcomes for patients >= 60, but not <60, years of age; no significant clinical benefit was found if prescribed beyond 5 days. Among patients >= 80 years of age, 3-4 doses of Comirnaty vaccine were associated with significantly lower risks for target outcomes. Policies should encourage COVID-19 vaccination, and oral antivirals should be made accessible to infected persons within 5 days of confirmed diagnosis.

引用

页码：70 / 78

页数：9

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