Mini-review: The neurobiology of treating substance use disorders with classical psychedelics

被引：17

作者：

Urban, Marvin M. ^{[1
,2
]}

Stingl, Moritz R. ^{[2
,3
]}

Meinhardt, Marcus W. ^{[1
,4
]}

机构：

[1] Heidelberg Univ, Inst Psychopharmacol, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany

[2] Heidelberg Univ, Interdisciplinary Ctr Neurosci, Heidelberg, Germany

[3] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA USA

[4] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Mol Neuroimaging, Mannheim, Germany

来源：

FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷

关键词：

psychedelics; addiction; psilocybin; hallucinogen; substance; dependency; plasticity; therapy; LYSERGIC-ACID DIETHYLAMIDE; GRAY-MATTER VOLUME; MEDIAL PREFRONTAL CORTEX; 5-HT2A RECEPTORS; DOPAMINE RELEASE; MOLECULAR NEUROBIOLOGY; ANTERIOR CINGULATE; NUCLEUS-ACCUMBENS; PYRAMIDAL NEURONS; COCAINE-SEEKING;

D O I：

10.3389/fnins.2023.1156319

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The potential of psychedelics to persistently treat substance use disorders is known since the 1960s. However, the biological mechanisms responsible for their therapeutic effects have not yet been fully elucidated. While it is known that serotonergic hallucinogens induce changes in gene expression and neuroplasticity, particularly in prefrontal regions, theories on how specifically this counteracts the alterations that occur in neuronal circuitry throughout the course of addiction are largely unknown. This narrative mini-review endeavors to synthesize well-established knowledge from addiction research with findings and theories regarding the neurobiological effects of psychedelics to give an overview of the potential mechanisms that underlie the treatment of substance use disorders with classical hallucinogenic compounds and point out gaps in the current understanding.

引用

页数：9

共 127 条

[81] Lysergic acid diethylamide and [-]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortex [J].