MicroRNA as a Diagnostic Tool, Therapeutic Target and Potential Biomarker in Cutaneous Malignant Melanoma Detection-Narrative Review

被引：14

作者：

Poniewierska-Baran, Agata ^{[1
]}

Zadroga, Lukasz ^{[2
]}

Danilyan, Edo ^{[3
]}

Malkowska, Paulina ^{[4
]}

Niedzwiedzka-Rystwej, Paulina ^{[1
]}

Pawlik, Andrzej ^{[2
]}

机构：

[1] Univ Szczecin, Inst Biol, Felczaka 3C, PL-71412 Szczecin, Poland

[2] Pomeranian Med Univ, Dept Physiol, Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland

[3] Inst Teknol Sepuluh Nopember, Fac Sci & Data Analyt, Biol Dept, Surabaya 60111, Indonesia

[4] Univ Szczecin, Doctoral Sch, PL-71412 Szczecin, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 06期

关键词：

miRNA; melanoma; biomarker; skin cancer; metastasis; clinical trials; CELL-CYCLE ARREST; UVEAL MELANOMA; EXPRESSION PROFILES; MIRNA EXPRESSION; PROGRESSION; GENE; IDENTIFICATION; PROLIFERATION; TRANSCRIPTION; PROGNOSIS;

D O I：

10.3390/ijms24065386

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanoma is the most serious type of skin cancer, causing a large majority of deaths but accounting for only similar to 1% of all skin cancer cases. The worldwide incidence of malignant melanoma is increasing, causing a serious socio-economic problem. Melanoma is diagnosed mainly in young and middle-aged people, which distinguishes it from other solid tumors detected mainly in mature people. The early detection of cutaneous malignant melanoma (CMM) remains a priority and it is a key factor limiting mortality. Doctors and scientists around the world want to improve the quality of diagnosis and treatment, and are constantly looking for new, promising opportunities, including the use of microRNAs (miRNAs), to fight melanoma cancer. This article reviews miRNA as a potential biomarker and diagnostics tool as a therapeutic drugs in CMM treatment. We also present a review of the current clinical trials being carried out worldwide, in which miRNAs are a target for melanoma treatment.

引用

页数：25

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