We introduce and study a discrete multi-period extension of the classical knapsack problem, dubbed generalized incremental knapsack. In this setting, we are given a set of n items, each associated with a non-negative weight, and T time periods with non-decreasing capacities W-1 <= ... <= W-T. When item i is inserted at time t, we gain a profit of p(it ); however, this item remains in the knapsack for all subsequent periods. The goal is to decide if and when to insert each item, subject to the time-dependent capacity constraints, with the objective of maximizing our total profit. Interestingly, this setting subsumes as special cases a number of recently-studied incremental knapsack problems, all known to be strongly NP-hard. Our first contribution comes in the form of a polynomial-time (1/2 - epsilon)-approximation for the generalized incremental knapsack problem. This result is based on a reformulation as a single-machine sequencing problem, which is addressed by blending dynamic programming techniques and the classical Shmoys-Tardos algorithm for the generalized assignment problem. Combined with further enumeration-based self-reinforcing ideas and new structural properties of nearly-optimal solutions, we turn our algorithm into a quasi-polynomial time approximation scheme (QPTAS). Hence, under widely believed complexity assumptions, this finding rules out the possibility that generalized incremental knapsack is APX-hard.