Impact of IL-6-174G/C, IL-10-1082A/G Gene Polymorphisms on Toxoplasma gondii infections

被引:0
作者
Hussein, Hama Hussein Hama [1 ]
Bilal, Samir Jawdat [2 ]
Azeez, Sarhang Hasan [3 ]
Aziz, Khalid Jabar [4 ]
Abdulkarimi, Rahim [5 ]
机构
[1] Qaladiza Sci High Sch, Educ Dept, Minist Educ, Gen Directorate Educ Raparin,Sub Directorate Pshd, Qaladiza, Iraq
[2] Salahaddin Univ Erbil, Coll Agr Engn Sci, Dept Fish, Erbil, Iraq
[3] Salahaddin Univ Erbil, Coll Educ, Biol Dept, Erbil, Iraq
[4] Salahaddin Univ Erbil, Coll Vet Med, Basic Sci Dept, Erbil, Iraq
[5] Boukan Off, Dept Environm, Boukan, West Azerbaijan, Iran
关键词
Toxoplasmosis; SNP; Cytokines; IL-6-174G/C; IL-10-1082A/G; TNF-alpha-308G/C; NITROGEN; PROMOTER; ETHYLENE; YIELD;
D O I
10.5281/zenodo.10212098
中图分类号
X176 [生物多样性保护];
学科分类号
090705 ;
摘要
Toxoplasma gondii is one of the most common intrauterine infections worldwide and the major cause of perinatal morbidity and mortality. This study aims to determine the genetic susceptibility of certain types of cytokine single nucleotide gene polymorphism to toxoplasmosis. Materials: the study involved 40 females with confirmed seropositive Toxoplasma gondii infection and 30 healthy females as the control group. Single nucleotide gene polymorphisms of IL-16-174G/C, IL-10-1082A/G, and TNF-alpha-308G/C were determined. IL-6-174G/C results showed no relation between GG and the disease, the protective effect of GC genotype, and CC as a risk factor with a 3-fold effect OR:3.22. C allele as a risk for the infection. For IL-10-1082A/G genotypes, the wild and mutant homozygotes were associated with the disease with almost 1.5 folded effects, OR: 1.46 and 1.56 respectively. While the mutant heterozygote has a protective effect against the disease, OR: 0.57. Conclusion: the study found a positive relation between the IL-6-174 CC genotype with 3 folded effects, and for IL-10-1082A/G the AA and AG were associated with the disease by 1.5 fold.
引用
收藏
页码:186 / 195
页数:10
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