Preoperative Osteopenia Is a Risk Factor for Death in Patients Undergoing Gastrectomy for Gastric Cancer

被引：5
作者：
Shimizu, Shota [1 ,2 ]
Matsunaga, Tomoyuki [1 ]
Sawata, Shohei [1 ]
Sakano, Yu [1 ]
Makinoya, Masahiro [1 ]
Shishido, Yuji [1 ]
Miyatani, Kozo [1 ]
Kono, Yusuke [1 ]
Murakami, Yuki [1 ]
Hanaki, Takehiko [1 ]
Kihara, Kyoichi [1 ]
Yamamoto, Manabu [1 ]
Tokuyasu, Naruo [1 ]
机构：
[1] Tottori Univ, Fac Med, Sch Med, Dept Surg,Div Gastrointestinal & Pediat Surg, Yonago, Japan
[2] Tottori Univ, Fac Med, Sch Med, Dept Surg,Div Gastrointestinal & Pediat Surg, 36-1 Nishi Cho, Yonago, 6838504, Japan
来源：
ANTICANCER RESEARCH | 2023年 / 43卷 / 08期
关键词：
Key Words; Gastric cancer; prognosis; osteopenia; NEUTROPHIL-LYMPHOCYTE RATIO; BONE-MINERAL DENSITY; C-REACTIVE PROTEIN; SURGICAL COMPLICATIONS; BREAST-CANCER; PROGNOSIS; GROWTH; CLASSIFICATION; SARCOPENIA; PREDICTOR;
D O I：
10.21873/anticanres.16548
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Preoperative osteopenia, defined as low bone mineral density (BMD), has been reported as a prognostic factor in patients with digestive tract cancers. However, the correlation between preoperative osteopenia and the prognosis of gastric cancer (GC) remains unclear. The aim of this study was to reveal the importance of preoperative osteopenia as a prognostic factor in patients undergoing gastrectomy for GC. Patients and Methods: We enrolled 251 patients who had undergone curative surgery for histopathologically diagnosed gastric adenocarcinoma from January 2008 to December 2012. BMD was calculated as the average pixel density (Hounsfield units) within a circle of the midvertebral core at the bottom of the 11th thoracic vertebra on preoperative computed tomography. Results: Osteopenia had a high area under the curve and predictive value for both overall survival (OS) and disease-specific survival (DSS). The study cohort was categorized into an osteopenia group and non-osteopenia group based on the optimal BMD cutoff values for OS (157.5) and DSS (195) determined by receiver operating characteristic analysis. The multivariate analysis revealed that OS (hazard ratio=3.607, p<0.001) and DSS (hazard ratio=2.797, p=0.03) were significantly worse in patients with than without preoperative osteopenia. Conclusion: Preoperative osteopenia is associated with poor OS and DSS in patients undergoing gastrectomy for GC.
引用
收藏
页码：3665 / 3672
页数：8
相关论文
共 41 条
[11]   Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma [J].
Harimoto, N. ;
Shirabe, K. ;
Yamashita, Y. -I. ;
Ikegami, T. ;
Yoshizumi, T. ;
Soejima, Y. ;
Ikeda, T. ;
Maehara, Y. ;
Nishie, A. ;
Yamanaka, T. .
BRITISH JOURNAL OF SURGERY, 2013, 100 (11) :1523-1530
[12]   Postoperative Long-Term Outcomes in Elderly Patients with Gastric Cancer and Risk Factors for Death from Other Diseases [J].
Hashimoto, Tadayoshi ;
Kurokawa, Yukinori ;
Mikami, Jota ;
Takahashi, Tsuyoshi ;
Miyazaki, Yasuhiro ;
Tanaka, Koji ;
Makino, Tomoki ;
Yamasaki, Makoto ;
Motoori, Masaaki ;
Kimura, Yutaka ;
Nakajima, Kiyokazu ;
More, Masaki ;
Doki, Yuichiro .
WORLD JOURNAL OF SURGERY, 2019, 43 (11) :2885-2893
[13]   Japanese classification of gastric carcinoma: 3rd English edition [J].
Sano T. ;
Kodera Y. .
GASTRIC CANCER, 2011, 14 (02) :101-112
[14]   Regulation of cancer cell migration and bone metastasis by RANKL [J].
Jones, DH ;
Nakashima, T ;
Sanchez, OH ;
Kozieradzki, I ;
Komarova, SV ;
Sarosi, I ;
Morony, S ;
Rubin, E ;
Sarao, R ;
Hojilla, CV ;
Komnenovic, V ;
Kong, YY ;
Schreiber, M ;
Dixon, SJ ;
Sims, SM ;
Khokha, R ;
Wada, T ;
Penninger, JM .
NATURE, 2006, 440 (7084) :692-696
[15]   Prognostic significance of osteopenia in patients with colorectal cancer: A retrospective cohort study [J].
Kamada, Teppei ;
Furukawa, Kenei ;
Takahashi, Junji ;
Nakashima, Keigo ;
Nakaseko, Yuichi ;
Suzuki, Norihiko ;
Yoshida, Masashi ;
Ohdaira, Hironori ;
Ikegami, Toru ;
Suzuki, Yutaka .
ANNALS OF GASTROENTEROLOGICAL SURGERY, 2021, 5 (06) :832-843
[16]   Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria [J].
Katayama, Hiroshi ;
Kurokawa, Yukinori ;
Nakamura, Kenichi ;
Ito, Hiroyuki ;
Kanemitsu, Yukihide ;
Masuda, Norikazu ;
Tsubosa, Yasuhiro ;
Satoh, Toyomi ;
Yokomizo, Akira ;
Fukuda, Haruhiko ;
Sasako, Mitsuru .
SURGERY TODAY, 2016, 46 (06) :668-685
[17]   Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis [J].
Kitami, Kazuhisa ;
Yoshihara, Masato ;
Tamauchi, Satoshi ;
Sugiyama, Mai ;
Koya, Yoshihiro ;
Yamakita, Yoshihiko ;
Fujimoto, Hiroki ;
Iyoshi, Shohei ;
Uno, Kaname ;
Mogi, Kazumasa ;
Ikeda, Yoshiki ;
Yokoi, Akira ;
Yoshikawa, Nobuhisa ;
Nishino, Kimihiro ;
Niimi, Kaoru ;
Nawa, Akihiro ;
Enomoto, Atsushi ;
Kajiyama, Hiroaki .
MATRIX BIOLOGY, 2022, 109 :70-90
[18]   Muscle-bone interactions: From experimental models to the clinic? A critical update [J].
Laurent, Michael R. ;
Dubois, Vanessa ;
Claessens, Frank ;
Verschueren, Sabine M. P. ;
Vanderschueren, Dirk ;
Gielen, Evelien ;
Jardi, Ferran .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2016, 432 (0C) :24-46
[19]   Estrogen Aggravates Tumor Growth in a Diffuse Gastric Cancer Xenograft Model [J].
Lee, Sunyi ;
Kim, Kyoung Mee ;
Lee, Seung Yeon ;
Jung, Joohee .
PATHOLOGY & ONCOLOGY RESEARCH, 2021, 27
[20]   Vitamin D suppressed gastric cancer cell growth through downregulating CD44 expression in vitro and in vivo [J].
Li, Qianxiu ;
Li, Yifan ;
Jiang, Houxiang ;
Xiao, Zhangang ;
Wu, Xu ;
Zhang, Hanyu ;
Zhao, Yueshui ;
Du, Fukuan ;
Chen, Yu ;
Wu, Zhigui ;
Li, Jing ;
Hu, Wei ;
Cho, Chi Hin ;
Shen, Jing ;
Li, Mingxing .
NUTRITION, 2021, 91-92
12345