Ovarian Clear Cell Carcinoma: Genomic Characterization, Pathogenesis and Targeted Therapy

被引：2
作者：
Xie, Yunkai [1 ]
Kong, Weimin [1 ,2 ]
Luo, Dan [1 ]
Chen, Shuning [1 ]
Zhao, Xiaoling [1 ]
Zhang, He [1 ]
机构：
[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Dept Gynecol Oncol, Beijing, Peoples R China
[2] Qi He Lou St, Beijing 100000, Peoples R China
来源：
ANTICANCER RESEARCH | 2023年 / 43卷 / 08期
关键词：
Endometriosis; ovarian clear cell carcinoma; endometriosis-associated ovarian cancer; oxidative stress; review; GLUTATHIONE-PEROXIDASE; 3; PTEN EXPRESSION; ENDOMETRIOSIS; CANCER; PROGRESSION; ADENOCARCINOMA; PROLIFERATION; INHIBITION; RESISTANCE; MUTATIONS;
D O I：
10.21873/anticanres.16515
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian clear cell carcinomas (OCCCs) are a subtype of ovarian epithelial tumors that arise from the malignant transformation of endometriosis (EMs). These tumors have distinctive molecular features, high malignant potential, low sensitivity to conventional chemotherapy, and poor prognosis. The process and mechanism of malignant transformation from EMs to OCCCs remains elusive. Elucidation of the molecular pathogenesis and drug resistance mechanism of OCCCs is essential to guide the clinical management and basic research of this disease. This paper provides a comprehensive review of the mechanisms of malignant transformation, genomic characteristics, drug resistance and targeted therapy of OCCCs. The review aims to provide new insights for the clinical management of advanced OCCCs.
引用
收藏
页码：3401 / 3410
页数：10
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