CRISPR-based m6A modification and its potential applications in telomerase regulation

被引：2

作者：

Yi, Mingliang ^{[1
]}

Wang, Mingyue ^{[1
]}

Xu, Yongjie ^{[1
]}

Cao, Zhikun ^{[1
]}

Ling, Yinghui ^{[1
,2
]}

Zhang, Zijun ^{[1
,2
]}

Cao, Hongguo ^{[1
,2
]}

机构：

[1] Anhui Agr Univ, Anhui Prov Key Lab Local Livestock & Poultry Genet, Hefei, Peoples R China

[2] Anhui Agr Univ, Coll Anim Sci & Technol, Hefei, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

基金：

中国国家自然科学基金; 安徽省自然科学基金;

关键词：

CRISPR system; m(6)A modification; epigenetic regulation; telomere; telomerase; STEM-LIKE CELLS; STRUCTURAL BASIS; RNA; PROTEIN; TRANSLATION; RECRUITMENT; METABOLISM; EXPRESSION; EVOLUTION;

D O I：

10.3389/fcell.2023.1200734

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m(6)A epigenetic modification plays an important role in the regulation of telomerase activity. Using CRISPR epigenome editing to analyze specific m(6)A modification sites in telomerase will provide an important tool for analyzing the molecular mechanism of m(6)A modification regulating telomerase activity. In this review, we clarified the relevant applications of CRISPR system, paid special attention to the regulation of m(6)A modification in stem cells and cancer cells based on CRISPR system, emphasized the regulation of m(6)A modification on telomerase activity, pointed out that m(6)A modification sites regulate telomerase activity, and discussed strategies based on telomerase activity and disease treatment, which are helpful to promote the research of anti-aging and tumor related diseases.

引用

页数：16

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