Association between serum uric acid levels of patients with gout and their complications and examination fees: A cross-sectional analysis

Objective: Correlation influence factor analysis of gout patients' serum uric acid (SUA) levels, their examination fees, and various complications were explored.Methods: From January 2017 to December 2021, 17 666 patients with gout were obtained. Conduct quartile grouping according to gout patients' SUA levels was used to compare the differences between groups in terms of examination fees and compli- cations. Kernel density estimation method was adopted to analyze the data distribu- tion, Spearman and Mantel-Haenszel chi 2 tests were used to analyze the correlation between SUA levels and examination fees and complications. Binary logistic regres- sion analysis was used to analyze the correlation influence factor between SUA levels and complications.Results: Of the 17 666 gout cases, 85.46% were male. Among them, 7637 (43.23%) were inpatients and 10 029 (56.77%) were outpatients. Compared with outpatients, age, SUA levels, and examination fees were significantly higher, and there were more complications among inpatients (P < 0.05). Correlation analysis revealed that outpa- tients and SUA levels of patients with gout were positively correlated with exami- nation fees, cardiovascular diseases, pulmonary diseases, liver diseases, and kidney diseases (P < 0.01). Binary logistic regression analysis showed that SUA level is an in- dependent influence factor for cardiovascular diseases, pulmonary diseases, liver dis- eases, and kidney diseases (odds ratio [95% confidence interval]: 1.002 [1.002-1.002], 1.001 [1.000-1.001], 1.003 [1.002-1.003], and 1.001 [1.001-1.002], respectively).Conclusions: As SUA levels increased, examination fees, cardiovascular disease, pul- monary disease, liver disease, and kidney disease complications increased. SUA level is an independent influence factor for the combination of gout with cardiovascular diseases, pulmonary diseases, liver diseases, and kidney diseases.