The LncRNA signature associated with cuproptosis as a novel biomarker of prognosis in immunotherapy and drug screening for clear cell renal cell carcinoma
被引:3
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作者:
Zhang, Lishuo
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机构:
Harbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Zhang, Lishuo
[1
]
Di, Longjiang
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机构:
Southern Med Univ, Coll Basic Med, Guangzhou, Guangdong, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Di, Longjiang
[2
]
Liu, Jinhui
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Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Liu, Jinhui
[3
]
Lei, Xianli
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Harbin Med Univ, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Lei, Xianli
[4
]
Gu, Maoli
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Harbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Gu, Maoli
[1
]
Zhang, Wenjing
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Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Zhang, Wenjing
[3
]
Wang, Yufu
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Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
Wang, Yufu
[3
]
机构:
[1] Harbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
[2] Southern Med Univ, Coll Basic Med, Guangzhou, Guangdong, Peoples R China
[3] Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China
[4] Harbin Med Univ, Harbin, Heilongjiang, Peoples R China
Cuproptosis is a new form of cell death, the second form of metal ion-induced cell death defined after ferroptosis. Recently, cuproptosis has been suggested to be associated with tumorigenesis. However, the relationship between cuproptosis and patient prognosis in clear cell renal cell carcinoma (ccRCC) in the context of immunotherapy remains unknown. The aim of this study was to investigate the correlation between cuproptosis-related long non-coding RNA (lncRNA) and ccRCC in terms of immunity as well as prognosis. Clinical information on lncRNAs associated with differences in cuproptosis genes in ccRCC and normal tissues was collected from The Cancer Genome Atlas (TCGA) dataset. Univariate Cox regression was used to screen lncRNAs. A total of 11 lncRNAs closely associated with cuproptosis were further screened and established using the least absolute shrinkage and selection operator (LASSO) algorithm and multivariate Cox regression, and the samples were randomly divided into training and test groups. A risk prognostic model was constructed using the training group, and the model was validated using the test group. We investigated the predictive ability of the prognostic risk model in terms of clinical prognosis, tumor mutation, immune escape, immunotherapy, tumor microenvironment, immune infiltration levels, and tumor drug treatment of ccRCC. Using the median risk score, patients were divided into low and high-risk groups. Kaplan-Meier curves showed that the overall survival (OS) of patients in the high-risk group was significantly worse than low-risk group (p < 0.001). Receiver operating characteristic (ROC) curves further validated the reliability of our model. The model consistently and accurately predicted prognosis at 1, 3, and 5 years, with an AUC above 0.7. Tumor cell genes generally precede morphological abnormalities; therefore, the model we constructed can effectively compensate for the traditional method of evaluating the prognosis of patients with renal cancer, and our model was also clinically meaningful in predicting ccRCC staging. In addition, lower model risk scores determined by mutational load indicated a good chance of survival. The high-risk group had greater recruitment of immune cells, while the anti-immune checkpoint immunotherapy was less efficacious overall than that of the low-risk group. Tumor and immune-related pathways were enriched, and anti-tumor agents were selected to improve the survival of ccRCC. This prognostic risk model is based on the levels of cuproptosis-associated lncRNAs and provides a new perspective in the clinical assessment and precise treatment of ccRCC.
机构:
Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
Chen, Zhuo
Liu, Xiao
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Zhejiang Chinese Med Univ, Shaoxing TCM Hosp, Shaoxing, Zhejiang, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
Liu, Xiao
Zhu, Zhengjie
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Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
Zhu, Zhengjie
Chen, Jinchao
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Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
Chen, Jinchao
Wang, Chen
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Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
Wang, Chen
Chen, Xi
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Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
Chen, Xi
Zhu, Shaoxing
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Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
Zhu, Shaoxing
Zhang, Aiqin
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Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R ChinaChinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China
机构:
China Med Univ, Hosp 1, Dept Urol, Shenyang, Liaoning, Peoples R ChinaChina Med Univ, Hosp 1, Dept Urol, Shenyang, Liaoning, Peoples R China
Wu, Zhengqi
Jin, Mingyue
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Shenzhen Univ, Gen Hosp, Dept Endocrinol, Shenzhen, Guangdong, Peoples R ChinaChina Med Univ, Hosp 1, Dept Urol, Shenyang, Liaoning, Peoples R China
Jin, Mingyue
Xin, Peng
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China Med Univ, Hosp 1, Dept Urol, Shenyang, Liaoning, Peoples R ChinaChina Med Univ, Hosp 1, Dept Urol, Shenyang, Liaoning, Peoples R China
Xin, Peng
Zhang, Hao
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China Med Univ, Hosp 1, Dept Urol, Shenyang, Liaoning, Peoples R ChinaChina Med Univ, Hosp 1, Dept Urol, Shenyang, Liaoning, Peoples R China
机构:
Cent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R China
Lin, Hang
Qu, Lingzhi
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Cent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R China
Qu, Lingzhi
Chen, Guanqiu
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Xi An Jiao Tong Univ, Dept Urol, Affiliated Hosp 1, Xian, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R China
Chen, Guanqiu
Zhang, Chunfang
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Cent South Univ, Xiangya Hosp, Dept Thorac Surg, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R China
Zhang, Chunfang
Lu, Liqing
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Cent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R China
Cent South Univ, Xiangya Hosp, Dept Thorac Surg, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R China
Lu, Liqing
Chen, Yongheng
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Cent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha, Peoples R China
机构:
Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei, Peoples R China
Anhui Med Univ, Inst Urol, Hefei, Peoples R ChinaAnhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Su, Yang
Zhang, Tianxiang
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Anhui Med Univ, Clin Med Coll 2, Hefei, Peoples R ChinaAnhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Zhang, Tianxiang
Tang, Jieqiong
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Anhui Med Univ, Clin Med Coll 2, Hefei, Peoples R ChinaAnhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Tang, Jieqiong
Zhang, Li
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Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei, Peoples R China
Anhui Med Univ, Inst Urol, Hefei, Peoples R ChinaAnhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Zhang, Li
Fan, Song
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Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei, Peoples R China
Anhui Med Univ, Inst Urol, Hefei, Peoples R ChinaAnhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Fan, Song
Zhou, Jun
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Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei, Peoples R China
Anhui Med Univ, Inst Urol, Hefei, Peoples R ChinaAnhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Zhou, Jun
Liang, Chaozhao
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Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei, Peoples R China
Anhui Med Univ, Inst Urol, Hefei, Peoples R ChinaAnhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China
机构:
Jilin Univ, Dept Ultrasound, China Japan Union Hosp, Changchun 130031, Jilin, Peoples R ChinaJilin Univ, Dept Ultrasound, China Japan Union Hosp, Changchun 130031, Jilin, Peoples R China
Cui, Tingting
Guo, Jiantao
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First Hosp Jilin Univ, Dept Cardiac Surg, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Ultrasound, China Japan Union Hosp, Changchun 130031, Jilin, Peoples R China
Guo, Jiantao
Sun, Zhixia
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Jilin Univ, Dept Ultrasound, China Japan Union Hosp, Changchun 130031, Jilin, Peoples R ChinaJilin Univ, Dept Ultrasound, China Japan Union Hosp, Changchun 130031, Jilin, Peoples R China
机构:
China Three Gorges Univ, Clinical Med Coll 2, Dept Urol Surg, Yichang 443000, Hubei, Peoples R ChinaChina Three Gorges Univ, Clinical Med Coll 2, Dept Urol Surg, Yichang 443000, Hubei, Peoples R China
Liu, Gangcheng
Xiong, Donglan
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Three Gorges Univ, Clin Med Coll 2, Dept Resp Med, Yichang 443000, Hubei, Peoples R ChinaChina Three Gorges Univ, Clinical Med Coll 2, Dept Urol Surg, Yichang 443000, Hubei, Peoples R China
Xiong, Donglan
Che, Zhifei
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Hainan Med Univ, Affiliated Hosp 1, Dept Urol, Haikou 570100, Hainan, Peoples R ChinaChina Three Gorges Univ, Clinical Med Coll 2, Dept Urol Surg, Yichang 443000, Hubei, Peoples R China
Che, Zhifei
Chen, Hualei
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Hainan Med Univ, Affiliated Hosp 2, Dept Urol Surg, Haikou 570100, Hainan, Peoples R China
Hainan Med Univ, Affiliated Hosp 2, Dept Urol Surg, 368 Yehai Rd, Haikou 570100, Hainan, Peoples R ChinaChina Three Gorges Univ, Clinical Med Coll 2, Dept Urol Surg, Yichang 443000, Hubei, Peoples R China
Chen, Hualei
Jin, Wenyi
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Wuhan Univ, Renmin Hosp, Dept Orthoped, Wuhan 430060, Hubei, Peoples R China
Wuhan Univ, Renmin Hosp, Dept Orthoped, 238 Zhangzhidong Rd, Wuhan 430060, Hubei, Peoples R ChinaChina Three Gorges Univ, Clinical Med Coll 2, Dept Urol Surg, Yichang 443000, Hubei, Peoples R China
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Xuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Xuzhou Med Univ, Sch Life Sci, Dept Biophys, Xuzhou 221004, Peoples R ChinaXuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Pang, Yipeng
Wang, Yushi
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Xuzhou Med Univ, Sch Life Sci, Dept Biophys, Xuzhou 221004, Peoples R ChinaXuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Wang, Yushi
Zhou, Xinyu
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Xuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Xuzhou Med Univ, Sch Life Sci, Dept Biophys, Xuzhou 221004, Peoples R ChinaXuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Zhou, Xinyu
Ni, Zhu
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Xuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Xuzhou Med Univ, Sch Life Sci, Dept Biophys, Xuzhou 221004, Peoples R ChinaXuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Ni, Zhu
Chen, Wenjing
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Xuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Xuzhou Med Univ, Sch Life Sci, Dept Biophys, Xuzhou 221004, Peoples R ChinaXuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Chen, Wenjing
Liu, Yi
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Xuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Xuzhou Med Univ, Sch Life Sci, Dept Biophys, Xuzhou 221004, Peoples R ChinaXuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Liu, Yi
Du, Wenlong
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Xuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
Xuzhou Med Univ, Sch Life Sci, Dept Biophys, Xuzhou 221004, Peoples R ChinaXuzhou Med Univ, Sch Life Sci, Dept Bioinformat, Xuzhou 221004, Peoples R China
机构:
Xuzhou Med Univ, Yancheng Clin Coll, Yancheng 224006, Peoples R ChinaXuzhou Med Univ, Yancheng Clin Coll, Yancheng 224006, Peoples R China
Zhang, Jiajun
Liu, Guocheng
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Xuzhou Med Univ, Yancheng Clin Coll, Yancheng 224006, Peoples R ChinaXuzhou Med Univ, Yancheng Clin Coll, Yancheng 224006, Peoples R China
Liu, Guocheng
Wang, Wei
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Xuzhou Med Univ, Yancheng Clin Coll, Yancheng 224006, Peoples R China
Yancheng 1 Peoples Hosp, Dept Urol, Yancheng 224006, Peoples R ChinaXuzhou Med Univ, Yancheng Clin Coll, Yancheng 224006, Peoples R China