Advances of Antimicrobial Peptide-Based Biomaterials for the Treatment of Bacterial Infections

被引：137

作者：

Li, Guoyu ^{[1
]}

Lai, Zhenheng ^{[1
]}

Shan, Anshan ^{[1
]}

机构：

[1] Northeast Agr Univ, Inst Anim Nutr, Harbin 150030, Peoples R China

来源：

ADVANCED SCIENCE | 2023年 / 10卷 / 11期

基金：

中国国家自然科学基金;

关键词：

antimicrobial peptides; bacterial infection; biomaterial delivery; design strategy; mouse models; treatment potential; ANTIBACTERIAL ACTIVITY; GOLD NANOPARTICLES; HUMAN LACTOFERRIN; HOST-DEFENSE; MOUSE MODEL; IN-VITRO; DESIGN; SELECTIVITY; GENTAMICIN; PLECTASIN;

D O I：

10.1002/advs.202206602

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Owing to the increase in multidrug-resistant bacterial isolates in hospitals globally and the lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have increased substantially. There is thus an urgent need to develop new antimicrobial drugs and their related formulations. In recent years, natural antimicrobial peptides (AMPs), AMP optimization, self-assembled AMPs, AMP hydrogels, and biomaterial-assisted delivery of AMPs have shown great potential in the treatment of bacterial infections. In this review, it is focused on the development prospects and shortcomings of various AMP-based biomaterials for treating animal model infections, such as abdominal, skin, and eye infections. It is hoped that this review will inspire further innovations in the design of AMP-based biomaterials for the treatment of bacterial infections and accelerate their commercialization.

引用

页数：23

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